Updated on 2023/06/23

写真a

 
GU Ping
 
Name of department
Faculty of Education, Science Education
Job title
Professor
Mail Address
E-mail address
External link

Education

  • 1991
    -
    1997

    Kyoto University   Graduate School, Division of Natural Science   Physics  

  • 1984
    -
    1988

    Harbin Institute of Technology   Faculty of Engineering   Optics  

Degree

  • Doctor(Science)

Academic & Professional Experience

  • 2011.04
    -
    Now

    Wakayama University   Faculty of Education   教授

  • 2001.04
    -
    2011.03

    Wakayama University   Faculty of Education

  • 2001.04

    Associate Professor, Faculty of Education

  • University of Wakayama

Association Memberships

  • 日本物理学会

  • 日本応用物理学会

  • 日本教育学会

Research Areas

  • Natural sciences / Semiconductors, optical and atomic physics

Classes (including Experimental Classes, Seminars, Graduation Thesis Guidance, Graduation Research, and Topical Research)

  • 2022   Experiments in Physics   Specialized Subjects

  • 2022   Science Education Contents   Specialized Subjects

  • 2022   Seminar of Scientific Education   Specialized Subjects

  • 2022   Introduction to Physics A   Specialized Subjects

  • 2022   Materials Science and Technology   Specialized Subjects

  • 2022   Seminar on Science Education (Physics B)   Specialized Subjects

  • 2022   Classical Mechanics   Specialized Subjects

  • 2022   Science education in juinor high school A   Specialized Subjects

  • 2022   Laboratory and Exercises in Natural Science (Physics B)   Specialized Subjects

  • 2022   Laboratory and Exercises in Natural Science (Physics A)   Specialized Subjects

  • 2021   Seminar on Science Education (Physics B)   Specialized Subjects

  • 2021   Experiments in Physics   Specialized Subjects

  • 2021   Seminar of Scientific Education   Specialized Subjects

  • 2021   Introduction to Physics A   Specialized Subjects

  • 2021   Laboratory and Exercises in Natural Science (Physics B)   Specialized Subjects

  • 2021   Laboratory and Exercises in Natural Science (Physics A)   Specialized Subjects

  • 2021   Science Education Contents   Specialized Subjects

  • 2021   Researching Science Teaching Materials   Specialized Subjects

  • 2021   Seminar on Science Education (Physics B)   Specialized Subjects

  • 2021   Science education in juinor high school A   Specialized Subjects

  • 2020   Experiments in Physics   Specialized Subjects

  • 2020   Science Education Contents   Specialized Subjects

  • 2020   Introduction to Physics A   Specialized Subjects

  • 2020   Materials Science and Technology   Specialized Subjects

  • 2020   Seminar on Science Education (Physics B)   Specialized Subjects

  • 2020   Classical Mechanics   Specialized Subjects

  • 2020   Science education in juinor high school A   Specialized Subjects

  • 2020   Laboratory and Exercises in Natural Science (Physics B)   Specialized Subjects

  • 2020   Laboratory and Exercises in Natural Science (Physics A)   Specialized Subjects

  • 2019   Science Education Contents   Specialized Subjects

  • 2019   Experiments in Physics   Specialized Subjects

  • 2019   Science Education Contents   Specialized Subjects

  • 2019   Seminar of Scientific Education   Specialized Subjects

  • 2019   Seminar of Scientific Education   Specialized Subjects

  • 2019   Researching Science Teaching Materials   Specialized Subjects

  • 2019   Introduction to Physics A   Specialized Subjects

  • 2019   Seminar on Science Education (Physics B)   Specialized Subjects

  • 2019   Science education in juinor high school A   Specialized Subjects

  • 2019   Laboratory and Exercises in Natural Science (Physics B)   Specialized Subjects

  • 2019   Laboratory and Exercises in Natural Science (Physics A)   Specialized Subjects

  • 2018   Science Education Contents   Specialized Subjects

  • 2018   Seminar of Scientific Education   Specialized Subjects

  • 2018   Introduction to Physics A   Specialized Subjects

  • 2018   Physics Experiment B   Specialized Subjects

  • 2018   Physics Experiment A   Specialized Subjects

  • 2018   Classical Mechanics   Specialized Subjects

  • 2018   Science education in juinor high school A   Specialized Subjects

  • 2018   Laboratory and Exercises in Natural Science (Physics B)   Specialized Subjects

  • 2018   Laboratory and Exercises in Natural Science (Physics A)   Specialized Subjects

  • 2017   NA   Liberal Arts and Sciences Subjects

  • 2017   NA   Specialized Subjects

  • 2017   NA   Specialized Subjects

  • 2017   Science Education Contents   Specialized Subjects

  • 2017   Introductory Physics A   Specialized Subjects

  • 2017   Introduction to Physics A   Specialized Subjects

  • 2017   Physics Experiment B   Specialized Subjects

  • 2017   Physics Experiment A   Specialized Subjects

  • 2017   Science education in juinor high school A   Specialized Subjects

  • 2017   Laboratory and Exercises in Natural Science (Physics A)   Specialized Subjects

  • 2016   Basic Mechanical Engineering   Specialized Subjects

  • 2016   Physics Experiment B   Specialized Subjects

  • 2016   Introductory Physics A   Specialized Subjects

  • 2016   Laboratory and Exercises in Natural Science (Physics B)   Specialized Subjects

  • 2016   Laboratory and Exercises in Natural Science (Physics A)   Specialized Subjects

  • 2016   Experiments of Mechanical Engineering   Specialized Subjects

  • 2016   Introduction to Physics A   Specialized Subjects

  • 2016   Physics Experiment A   Specialized Subjects

  • 2016   Seminar on Science Education (Physics B)   Specialized Subjects

  • 2016   Classical Mechanics   Specialized Subjects

  • 2016   Science education in juinor high school A   Specialized Subjects

  • 2015   Science education in juinor high school B   Specialized Subjects

  • 2015   Laboratory and Exercises in Natural Science (Physics A)   Specialized Subjects

  • 2015   Physics Experiment A   Specialized Subjects

  • 2015   Introduction to Physics A   Specialized Subjects

  • 2015   Introductory Physics A   Specialized Subjects

  • 2015   Wander in Natural Science   Liberal Arts and Sciences Subjects

  • 2015   Classical Mechanics   Specialized Subjects

  • 2015   Laboratory and Exercises in Natural Science (Physics B)   Specialized Subjects

  • 2015   Physics Experiment B   Specialized Subjects

  • 2015   Introductory Physics B   Specialized Subjects

  • 2014   Introductory Physics B   Specialized Subjects

  • 2014   Introductory Physics A   Specialized Subjects

  • 2014   Introduction to Physics A   Specialized Subjects

  • 2014   Physics Experiment B   Specialized Subjects

  • 2014   Physics Experiment A   Specialized Subjects

  • 2014   Seminar on Science Education (Physics B)   Specialized Subjects

  • 2014   Classical Mechanics   Specialized Subjects

  • 2014   Laboratory and Exercises in Natural Science (Physics B)   Specialized Subjects

  • 2014   Laboratory and Exercises in Natural Science (Physics A)   Specialized Subjects

  • 2014   Wander in Natural Science   Liberal Arts and Sciences Subjects

  • 2013   Introductory Physics B   Specialized Subjects

  • 2013   Introductory Physics A   Specialized Subjects

  • 2013   Introduction to Physics A   Specialized Subjects

  • 2013   Physics Experiment B   Specialized Subjects

  • 2013   Physics Experiment A   Specialized Subjects

  • 2013   Seminar on Science Education (Physics B)   Specialized Subjects

  • 2013   Classical Mechanics   Specialized Subjects

  • 2013   Laboratory and Exercises in Natural Science (Physics B)   Specialized Subjects

  • 2013   Laboratory and Exercises in Natural Science (Physics A)   Specialized Subjects

  • 2013   Natural Science of Culture   Liberal Arts and Sciences Subjects

  • 2012   Seminar on Science Education (Physics B)   Specialized Subjects

  • 2012   Seminar on Natural Environments (Material Science A)   Specialized Subjects

  • 2012   Laboratory and Exercises in Natural Science (Physics A)   Specialized Subjects

  • 2012   Physics Experiment A   Specialized Subjects

  • 2012   Introduction to Physics A   Specialized Subjects

  • 2012   Natural Science of Culture   Liberal Arts and Sciences Subjects

  • 2012   Classical Mechanics   Specialized Subjects

  • 2012   Laboratory and Exercises in Natural Science (Physics B)   Specialized Subjects

  • 2012   Physics Experiment B   Specialized Subjects

  • 2011   NA   Specialized Subjects

  • 2011   Classical Mechanics   Specialized Subjects

  • 2011   Physics Experiment B   Specialized Subjects

  • 2011   Physics Experiment A   Specialized Subjects

  • 2011   Seminar on Natural Environments (Material Science A)   Specialized Subjects

  • 2011   Seminar on Science Education (Physics B)   Specialized Subjects

  • 2011   Laboratory and Exercises in Natural Science (Physics B)   Specialized Subjects

  • 2011   Laboratory and Exercises in Natural Science (Physics A)   Specialized Subjects

  • 2011   Introduction to Physics A   Specialized Subjects

  • 2011   Natural Science of Culture   Liberal Arts and Sciences Subjects

  • 2010   Introduction to Physics A   Specialized Subjects

  • 2010   Introduction to Physics A   Specialized Subjects

  • 2010   NA   Specialized Subjects

  • 2010   Physics Experiment B   Specialized Subjects

  • 2010   Physics Experiment A   Specialized Subjects

  • 2010   Seminar on Natural Environments (Material Science A)   Specialized Subjects

  • 2010   Experimental Physics for Environmental Studies   Specialized Subjects

  • 2010   Seminar on Science Education (Physics B)   Specialized Subjects

  • 2010   Classical Mechanics   Specialized Subjects

  • 2010   Laboratory and Exercises in Natural Science (Physics B)   Specialized Subjects

  • 2010   Laboratory and Exercises in Natural Science (Physics A)   Specialized Subjects

  • 2009   Laboratory and Exercises in Natural Science (Physics A)   Specialized Subjects

  • 2009   Physics Experiment B   Specialized Subjects

  • 2009   Physics Experiment A   Specialized Subjects

  • 2009   Seminar on Natural Environments (Material Science A)   Specialized Subjects

  • 2009   Laboratory and Exercises in Natural Science (Physics B)   Specialized Subjects

  • 2009   Classical Mechanics   Specialized Subjects

  • 2009   Introduction to Physics A   Specialized Subjects

  • 2009   Physics A   Liberal Arts and Sciences Subjects

  • 2009   Light and Environment   Specialized Subjects

  • 2008   NA   Specialized Subjects

  • 2008   Physics Experiment B   Specialized Subjects

  • 2008   Physics Experiment A   Specialized Subjects

  • 2008   Seminar on Natural Environments (Material Science A)   Specialized Subjects

  • 2008   Seminar on Science Education (Physics B)   Specialized Subjects

  • 2008   Experimental Physics for Environmental Studies   Specialized Subjects

  • 2008   Classical Mechanics   Specialized Subjects

  • 2008   Light and Environment   Specialized Subjects

  • 2008   Physics A   Liberal Arts and Sciences Subjects

  • 2005   NA   Specialized Subjects

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Satellite Courses

  • 2021   NA   Liberal Arts and Sciences Subjects

  • 2019   NA   Liberal Arts and Sciences Subjects

  • 2018   NA   Liberal Arts and Sciences Subjects

  • 2017   NA   Liberal Arts and Sciences Subjects

  • 2016   NA   Liberal Arts and Sciences Subjects

  • 2015   NA   Liberal Arts and Sciences Subjects

  • 2014   NA   Liberal Arts and Sciences Subjects

  • 2013   NA   Liberal Arts and Sciences Subjects

  • 2012   NA   Liberal Arts and Sciences Subjects

  • 2011   NA   Liberal Arts and Sciences Subjects

  • 2010   NA   Liberal Arts and Sciences Subjects

  • 2009   NA   Liberal Arts and Sciences Subjects

▼display all

Independent study

  • 2022   液中レーザーアブレーション法を用いてナノ粒子の作成

  • 2021   液中レーザーアブレーション法を用いてナノ粒子の作成

  • 2020   液中レーザーアブレーション法を用いてナノ粒子の作成

  • 2019   液中レーザーアブレーション法を用いてナノ粒子の作成

  • 2018   液中レーザーアブレーション法を用いてナノ粒子の作成

  • 2017   液中レーザーアブレーション法を用いてナノ粒子の作成

  • 2016   液中レーザーアブレーション法を用いてナノ粒子の作成

  • 2015   液中レーザーアブレーション法を用いてナノ粒子の作成

  • 2014   液中レーザーアブレーション法を用いてナノ粒子の作成

  • 2013   液中レーザーアブレーション法を用いてナノ粒子の作成

  • 2012   液中レーザーアブレーション法を用いてナノ粒子の作成

  • 2011   液中レーザーアブレーション法を用いてナノ粒子の作成

  • 2010   液中レーザーアブレーション法を用いて作成したナノ粒子の生成効率の研究

  • 2009   液中レ-ザ-アブレ-ション法の応用

  • 2008   ナノ粒子の水溶液作成

  • 2007   難溶性物質の水溶液の作成

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Classes

  • 2021   Special Practice in Quantum Mechanics   Master's Course

  • 2020   Research Work   Master's Course

  • 2020   Special Practice in Quantum Mechanics   Master's Course

  • 2019   Research Work   Master's Course

  • 2019   Special Practice in Quantum Mechanics   Master's Course

  • 2018   Special Practice in Quantum Mechanics   Master's Course

  • 2018   Quantum Mechanics   Master's Course

  • 2017   Quantum Mechanics   Master's Course

  • 2016   Research Work  

  • 2016   Quantum Mechanics  

  • 2016   Quantum Mechanics  

  • 2016   Special Practice in Quantum Mechanics   Master's Course

  • 2015   Quantum Mechanics  

  • 2015   A Practical Study on Developing Curriculum and Lesson B  

  • 2014   Research Work  

  • 2014   Special Practice in Quantum Mechanics  

  • 2014   Quantum Mechanics  

  • 2014   A Practical Study on Developing Curriculum and Lesson B  

  • 2013   Research Work  

  • 2013   Special Practice in Quantum Mechanics  

  • 2013   Quantum Mechanics  

  • 2013   A Practical Study on Developing Curriculum and Lesson B  

  • 2013   Experiments in science ⅠA  

  • 2012   Special Practice in Quantum Mechanics  

  • 2012   Quantum Mechanics  

  • 2012   Experiments in science ⅠA  

  • 2012   A Practical Study on Developing Curriculum and Lesson B  

  • 2012   Research Work  

  • 2011   Research Work  

  • 2011   Special Practice in Quantum Mechanics  

  • 2011   Quantum Mechanics  

  • 2011   Experiments in science ⅠA  

  • 2010   Experiments in science ⅠA  

  • 2010   Quantum Mechanics  

  • 2010   Special Practice in Quantum Mechanics  

  • 2009   Experiments in science ⅠA   Master's Course

  • 2009   Quantum Mechanics   Master's Course

  • 2008   Experiments in science ⅠA   Master's Course

  • 2007   Quantum Mechanics   Master's Course

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Research Interests

  • ナノ粒子

  • nano particles

Published Papers

  • Probiotics protect against hepatic steatosis in tris (2-chloroethyl) phosphate-induced metabolic disorder of mice via FXR signaling

    Yang D, Wei X, Zhang B, Zhu R, Hu H, Fan X, Du H, Chen X, Zhang Z, Zhao M, Oh Y, Gu Ning

    Food Chem Toxicol   169 ( 113440 )   2022.11  [Refereed]

    DOI

  • Malting barley carbon dots-mediated oxidative stress promotes insulin resistance in mice via NF-κB pathway and MAPK cascade.

    Zhang B, Yu L, Zhu R, Wei X, Fan X, Hu H, Yang D, Du H, Zhao M, Li L, Oh Y, Feng Y, Gu Ning

    J Nanobiotechnology   20 ( 331 ) 1 - 19   2022.07  [Refereed]

    DOI

  • Thiamethoxam induces nonalcoholic fatty liver disease in mice via methionine metabolism disturb via nicotinamide N-methyltransferase overexpression

    Daqian Yang, Xiaoting Zhang, Lei Yue, Hailong Hu, Xiangjuan Wei, Qian Guo, Boya Zhang, Xingpei Fan, Yuan Xin, Yuri Oh, Ning Gu

    Chemosphere ( Elsevier BV )  273   129727 - 129727   2021.06  [Refereed]

    DOI

  • Probiotics protect against hepatic steatosis in tris (2-chloroethyl) phosphate-induced metabolic disorder of mice via FXR signaling

    Yang D, Wei X, Zhang B, Zhu R, Hu H, Fan X, Du H, Chen X, Zhang Z, Zhao M, Oh Y, Gu Ning

      169 ( 113440 )   2020.09  [Refereed]

    DOI

  • Molecular mechanisms underlying zinc oxide nanoparticle induced insulin resistance in mice

    Hu H, Guo Q, Fan X, Wei X, Yang D, Zhang B, Liu J, Wu Q, Oh Y, Feng Y, Chen K, Hou L, Gu N

    Nanotoxicology.   14 ( 1 ) 59 - 76   2020.02  [Refereed]

  • The saturated fatty acid palmitate induces insulin resistance through Smad3-mediated down-regulation of FNDC5 in myotubes.

    Qian Guo, Xiangjuan Wei, Hailong Hu, Daqian Yang, Boya Zhang, Xingpei Fan, Jing Liu, Hongjuan He, Yuli Oh, Qiong Wu, Yao Zhang, Chuanpeng Liu, Changlin Whang, Ning Gu

    Biochemical and Biophysical Research Communications. Vol. 520(3):619-626, 2019.   5206 ( 3 ) 619 - 626   2019.12  [Refereed]

  • Silicon dioxide nanoparticles induce insulin resistance through endoplasmic reticulum stress and generation of reactive oxygen species.

    Hailong Hu, Xingpei Fan, Qian Guo, Xiangjuan Wei, Daqian Yang, Boya Zhang, Jing Liu, Qiong Wu, Yuri Oh, Yujie Feng, Kun Chen, Liping Hou, Ning Gu

    Particle and Fibre Toxicology   Vol.16 ( 41 ) 1 - 18   2019.11  [Refereed]

  • C/EBPβ mediates palmitate-induced musclin expression via the regulation of PERK/ATF4 pathways in myotubes.

    Qian Guo, Hailong Hu, Xiaohuan Liu, DaQian Yang, Yao Yin, Boya Zhang, Hongjuan He, Yuri Oh, Qiong Wu, Chuanpeng Liu, Ning Gu

    Am J Physiol Endocrinol Metab.   316 ( 6 ) E1081-E1092 - E1092   2019.06  [Refereed]

  • Glucosamine induces increased musclin gene expression through endoplasmic reticulum stress-induced unfolding protein response signaling pathways in mouse skeletal muscle cells.

    1) Qian Guo,Hailong Hu,Ying Zhoua,Yuheng Yan,Xiangjuan Wei,Xingpei Fan,Daqian Yang,Hongjuan He,Yuri Oh,Kun Chen,Qiong Wu,Chuanpeng Liu,Ning Gu.

    Food Chem Toxicol,   125   95 - 105   2019.03  [Refereed]

  • RNA sequencing analysis shows that titanium dioxide nanoparticles induce endoplasmic reticulum stress, which has a central role in mediating plasma glucose in mice

    Hailong Hu, Li Li, Qian Guo, He Zong, Yuheng Yan, Yao Yin, Yu Wang, Yuri Oh, Yujie Feng, Qiong Wu, Ning Gu

    Nanotoxicology ( Taylor and Francis Ltd )  12 ( 4 ) 341 - 356   2018.04  [Refereed]

     View Summary

    Titanium dioxide nanoparticles (TiO2NPs) constitute the top five NPs in use today. In this study, oral administration of 50, 100, and 200 mg/kg body weight (b.w.) TiO2NPs increases plasma glucose in mice, whereas 10 and 20 mg/kg b.w. TiO2NPs did not. RNA sequencing (RNA-seq) technology was used to investigate genome-wide effects of TiO2NPs. Clustering analysis of the RNA-seq data showed the most significantly enriched gene ontology terms and KEGG pathways related to the endoplasmic reticulum (ER) and ER stress. Molecular biology verification showed that 50 mg/kg b.w. and higher doses TiO2NPs activated a xenobiotic biodegradation response and increased expression of cytochrome P450 family genes in mouse livers, thus inducing ER stress in mice. ER stress-activated MAPK and NF-κB pathways and induced an inflammation response, resulting in phosphorylation of the insulin receptor substrate 1 and, consequently, insulin resistance. This was the main mechanism by which TiO2NPs increased plasma glucose in mice. Meanwhile, ER stress disturbed the monooxygenase system, and thus generated reactive oxygen species (ROS). Relief of ER stress with 4-phenylbutyric acid inhibited all the above effects of TiO2NPs, including the generation of ROS. Therefore, TiO2NP-induced ER stress was a decisive factor with a central role in plasma glucose disturbance in mice.

    DOI

  • Hypoxia in 3T3-L1 adipocytes suppresses adiponectin expression via the PERK and IRE1 unfolded protein response

    Qian Guo, Sanli Jin, Hailong Hu, Ying Zhou, Yuheng Yan, He Zong, Yu Wang, Hongjuan He, Yuri Oh, Chuanpeng Liu, Ning Gu

    Biochemical and Biophysical Research Communications ( Elsevier B.V. )  493 ( 1 ) 346 - 351   2017.11  [Refereed]

     View Summary

    Adiponectin, an adipocytokine produced by adipocytes, functions as an anti-inflammatory and anti-apoptotic substance, while also enhancing insulin sensitivity. Patients or model animals with obesity or diabetes typically present attenuated expression of adiponectin. Moreover, obesity and diabetes are often accompanied with hypoxia in adipose tissue, which may result in endoplasmic reticulum (ER) stress as well as low expression of adiponectin. The purpose of this study was to investigate the specific role of the unfolded protein response (UPR) involved in the low expression of adiponectin induced by hypoxia. Subjecting 3T3-L1 adipocytes to hypoxia significantly reduced adiponectin expression and activated the PERK and IRE1 signaling pathways in a time-dependent manner. The ATF6 signaling pathway showed no obvious changes with hypoxia treatment under a similar time course. Moreover, the down-regulated expression of adiponectin induced by hypoxia was relieved once the PERK and IRE1 signaling pathways were suppressed by the inhibitors GSK2656157 and 4μ8C, respectively. Overall, these data demonstrate that hypoxia can suppress adiponectin expression and activate the PERK and IRE1 signaling pathways in differentiated adipocytes, and this two pathways are involved in the suppression of adiponectin expression induced by hypoxia.

    DOI

  • Growth of zinc sulfide by mist chemical vapor deposition depending on mist size and thermal conditions in susceptor: Growth of zinc sulfide by mist chemical vapor

    Kazuyuki Uno, Yuichiro YAMASAKI、Gu PING, Ichiro Tanaka

    physica status solidi (c)   13   7 - 9   2016.04  [Refereed]

  • A mechanistic study to increase understanding of titanium dioxide nanoparticles-increased plasma glucose in mece

    Hu Hailong, Guo Qian, Wang Changlin, Ma Xiao, He Hongjuan, Oh Yuri, Feng Yujie, Wu Qiong, Ning Gu

    Food and Chemical Toxicology   95   175 - 187   2016  [Refereed]

  • Growth of zinc sulfide by mist chemical vapor deposition depending on mist size and thermal conditions in susceptor

    Kazuyuki Uno, Yuichiro Yamasaki, Ping Gu, Ichiro Tanaka

    PHYSICA STATUS SOLIDI C: CURRENT TOPICS IN SOLID STATE PHYSICS, VOL 13 NO 7-9 ( WILEY-V C H VERLAG GMBH )  13 ( 7-9 ) 448 - 451   2016  [Refereed]

     View Summary

    Zinc sulfide (ZnS) films were successfully grown by using mist chemical vapor deposition (mist-CVD) with fine-channel susceptor made of quartz. For the investigation of growth dynamics, two types of mist generators and two types of susceptors were prepared and distribution profiles of film thickness were examined. Thermal efficiency of susceptor depends on heat-penetration efficiency and line-velocity of the mists, which are influenced by the fine-channel gap-height of the susceptors. Using larger size of mists requires higher thermal efficiency in susceptor to obtain a flat thickness distribution. This result indicates that the optimization of the mist size and the susceptor structure is important for the film uniformity of grown films by the mist-CVD. (C) 201 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

    DOI

  • Palmitate increases musclin gene expression through activation of PERK signaling pathway in C2C12 myotubes

    Ning Gu, Qian Guo, Ke Mao, Hailong Hu, Sanli Jin, Ying Zhou, Hongjuan He, Yuri Oh, Chuanpeng Liu, Qiong Wu

    Biochemical and Biophysical Research Communications ( Academic Press Inc. )  467 ( 3 ) 521 - 526   2015.11  [Refereed]

     View Summary

    Musclin is a type of muscle-secreted cytokine and its increased gene expression induces insulin resistance in type 2 diabetes. However, the mechanism underlying increased musclin gene expression is currently unclear. Excessive saturated fatty acids (SFA) can activate the secretion of several muscle-secreted cytokines as well as endoplasmic reticulum (ER) stress pathway, thereby contributing to the development of type 2 diabetes. The purpose of this study was to investigate the mechanisms responsible for the effect of palmitate, the most abundant SFA in the plasma, on the gene expression of musclin in C2C12 myotubes. Treatment of C2C12 myotubes with palmitate or tunicamycin significantly increased the expression of musclin as well as ER stress-related genes, but treatment with oleate did not. Pre-treatment of C2C12 myotubes with 4-phenyl butyrate suppressed the expression of ER stress-related genes, simultaneously, resulting in decreased expression of the musclin gene induced by palmitate or tunicamycin. These results indicate that ER stress is related to palmitate-induced musclin gene expression. Moreover, palmitate-induced musclin gene expression was significantly inhibited in C2C12 myotubes when PERK pathway signaling was suppressed by knockdown of the PERK gene or treatment with GSK2656157, a PERK autophosphorylation inhibitor. However, there was no difference in the palmitate-induced musclin gene expression when IRE1 and ATF6 signaling pathways were suppressed by knockdown of the IRE1 and ATF6 genes. These findings suggest that palmitate increases musclin gene expression via the activation of the PERK signaling pathway in C2C12 myotubes.

    DOI

  • Growth mechanism of zinc sulfide films by mist chemical vapor deposition

    Yuichiro Yamasaki, Kazuyuki Uno, Gu Ping, Ichiro Tanaka

    Zairyo/Journal of the Society of Materials Science, Japan ( Society of Materials Science Japan )  64 ( 9 ) 707 - 710   2015.09  [Refereed]

     View Summary

    The mist chemical vapor deposition (mist CVD) method, which uses ultrasonically atomized solutions as sources, is an environmental friendly and cost-effective technology for the growth of compound semiconductors. This growth process is realized under atmospheric pressure and allows us to use many kinds of salts, complexes, and compounds with low toxicity for sources. Using the oxidizability of water including the source, most of the previous reports of the mist-CVD method are on oxide materials. In this study, we fabricated zinc sulfide (ZnS) films by mist-CVD method using thiourea-based water solutions as sources. Investigating the growth of ZnS by mist-CVD under various growth conditions and experimental setups, we proposed zinc-chloride complexes are necessary for the growth of ZnS and vaporized mist sources act as precursors.

    DOI

  • Titanium dioxide nanoparticles increase plasma glucose via reactive oxygen species-induced insulin resistance in mice.

    Hu Hailong, Guo Qian, Wang Changlin, Ma Xiao, He Hongjuan, Oh Yuri, Feng Yujie, Wu Qiong, Gu Ning

    Journal of Applied Toxicology   35 ( 10 ) 1122 - 1132   2015  [Refereed]

  • Effects of oral administration of titanium dioxide fine-sized particles on plasma glucose in mice

    Ning Gu, Hailong Hu, Qian Guo, Sanli Jin, Changlin Wang, Yuri Oh, Yujie Feng, Qiong Wu

    Food and Chemical Toxicology   86   124 - 131   2015  [Refereed]

  • 4-Phenylbutyric Acid Increases GLUT4 Gene Expression through Suppression of HDAC5 but not Endoplasmic Reticulum Stress

    Hailong Hu, Li Li, Changlin Wang, Hongjuan He, Ke Mao, Xiao Ma, Ruoyu Shi, Yuri Oh, FengWei Zhang, Ying Lu, Qiong Wu, Ning Gu

    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY ( KARGER )  33 ( 6 ) 1899 - 1910   2014  [Refereed]

     View Summary

    Background:The chemical chaperone 4-phenylbutyric acid (4-PBA) has been shown to relieve endoplasmic reticulum (ER) stress. Therefore, it improves insulin sensitivity and promotes glucose metabolism in skeletal muscle. Glucose transporter type 4 (GLUT4), as a major glucose transporter protein, plays a central role in glucose metabolism. Until now, it has been unclear whether 4-PBA affects GLUT4 gene expression and thus, contributes to glucose metabolism. Methods: C2C12 myotubes were treated with 4-PBA, tunicamycin or butyrate and subjected to Western blot and RT-PCR. Results: 4-PBA-treated C2C12 myotubes increased GLUT4 expression and promoted glucose metabolism. Most interestingly, GLUT4 gene expression induced by 4-PBA was not associated with ER stress even in the presence of tunicamycin, an ER stress inducer. Moreover, we also found that 4-PBA inhibited histonedeacetylase 5 (HDAC5) expression in C2C12 myotubes, resulting in hyperacetylation of the histone H3 at the myocyte enhancer factor 2 (MEF2) binding site. This increased the binding of MEF2A to the site on the GLUT4 promoter, resulting in increased GLUT4 expression. Conclusions: Our data indicate that 4-PBA increases GLUT4 expression by acetylating the MEF2 site to increase the MEF2A binding through a mechanism that involves suppression of the HDAC5 pathway, but without involving ER stress. Copyright (C) 2014 S Karger AG, Basel

    DOI

  • Terahertz-photomixing efficiency of a photoconductive antenna embedded in a three-dimensional photonic crystal

    M Iida, M Tani, P Gu, K Sakai, M Watanabe, H Kitahara, S Kato, M Suenaga, H Kondo, MW Takeda

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS ( INST PURE APPLIED PHYSICS )  42 ( 12A ) L1442 - L1445   2003.12  [Refereed]

     View Summary

    We report on generation of coherent terahertz radiation by photomixing with a photoconductive antenna placed in a three-dimensional photonic crystal cavity. We observed efficiency peaks around the frequencies near the photonic bandedges and at the planar defect modes. The efficiency peaks observed near the photonic bandedges are associated with the increase of the optical mode density at the bandedge. The relatively low efficiency at the planar defect mode frequencies are explained by the mode diffusion in the lateral direction of the defect layer.

    DOI

  • Highly efficient terahertz radiation from YBa2Cu3O7-delta thin film log-periodic antennas

    M Tonouchi, H Saijo, M Hangyo, O Morikawa, P Gu, M Tani, K Sakai

    PHYSICA C ( ELSEVIER SCIENCE BV )  357   1600 - 1602   2001.08  [Refereed]

     View Summary

    We report on the radiation power of the terahertz (THz) beam from YBa2Cu3O7-delta (YBCO) thin film antennas. InSb hot-electron bolometer is used to estimate the radiation power after being calibrated in the THz beam generation and detection system. The 100-nm-thick and 30-mum-wide YBCO thin film bridges are connected to a self-complimentary log-periodic toothed planar antenna or a bow-tie antenna. Femtosecond optical pulses are focused onto the center bridge of the antennas being biased with a current up to 1 A. The detected power increases in proportion with increasing bias current, and reaches over 22 muW in the average at an excitation power of 98 mW. (C) 2001 Elsevier Science BY. All rights reserved.

  • Generation of THz radiation by excitation of InAs with a femtosecond free-electron laser

    M Tani, S Kono, P Gu, K Sakai, M Usami, M Shinn, JF Gubeli, G Neil, JZ Xu, R Kersting, XC Zhang

    ULTRAFAST ELECTRONICS AND OPTOELECTRONICS, PROCEEDINGS ( OPTICAL SOC AMERICA )  49   166 - 170   2001  [Refereed]

     View Summary

    Terahertz (THz) radiation is generated by exciting an un-doped InAs wafer with a femtosecond free-electron laser (FEL) at the Thomas Jefferson National Accelerator Facility. A microwatt level of THz radiation is detected from the unbiased InAs emitter when it is excited with the femtosecond FEL pulses operated at a wavelength of 1.06 mum and 10 W average power.

  • Ultrabroadband detection of THz radiation by LT-GaAs photoconductive antenna gated with 15-fs laser pulses

    S Kono, M Tani, P Gu, K Sakai

    ULTRAFAST PHENOMENA XII ( SPRINGER-VERLAG BERLIN )  66   218 - 220   2001  [Refereed]

     View Summary

    Ultrabroadband detection of terahertz radiation is demonstrated with a low-temperature-grown GaAs photoconductive antenna gated with 15-fs laser pulses. The observed spectra extends up to 20 THz and shows an absorption band between 7 similar to 10 THz due to the phonon resonance in GaAs substrate of the detector.

  • Coherent THz wave generation by photomixing in photonic crystal cavity

    M Tani, P Gu, K Sakai, M Suenaga, H Kondo, H Kitahara, MW Takeda

    CLEO(R)/PACIFIC RIM 2001, VOL I, TECHNICAL DIGEST ( IEEE )    196 - 197   2001  [Refereed]

     View Summary

    We demonstrate generation of coherent. terahertz radiation by photomixing with a photoconductive antenna placed in a 3-D photonic crystal cavity. We observe a sharp gain peak at a frequency in the photonic bandgap, suggesting a cavity effect for it localized defect mode.

  • Coherent phonons in InSb and their properties from femtosecond pump-probe experiments

    OV Misochko, P Gu, K Sakai

    PHYSICA B-CONDENSED MATTER ( ELSEVIER SCIENCE BV )  293 ( 1-2 ) 33 - 37   2000.12  [Refereed]

     View Summary

    We report the ultrafast impulsive excitation of coherent LO phonons with the frequency of 5.57 THz in InSb. These phonons, when generated by femtosecond laser pulses. exhibit phase-dependent fluctuation properties. that is, the variance of coherent amplitude is a function of time delay. The variance oscillations occur, for short time delays, at twice the frequency of the coherent amplitude. (C) 2000 Elsevier Science B.V. All rights reserved.

  • Detection of up to 20 THz with a low-temperature-grown GaAs photoconductive antenna gated with 15 fs light pulses

    S Kono, M Tani, P Gu, K Sakai

    APPLIED PHYSICS LETTERS ( AMER INST PHYSICS )  77 ( 25 ) 4104 - 4106   2000.12  [Refereed]

     View Summary

    We report on the ultrabroadband coherent detection of radiation in wavelengths spanning from far to midinfrared with a low-temperature-grown GaAs photoconductive dipole antenna gated with 15 fs light pulses. The detected spectral frequency exceeds 20 THz. (C) 2000 American Institute of Physics. [S0003-6951(00)05451-6].

  • Temperature dependence of terahertz radiation from n-type InSb and n-type InAs surfaces

    S Kono, P Gu, M Tani, K Sakai

    APPLIED PHYSICS B-LASERS AND OPTICS ( SPRINGER-VERLAG )  71 ( 6 ) 901 - 904   2000.12  [Refereed]

     View Summary

    The azimuthal angle dependence and the temperature dependence of terahertz (THz) radiation generated from n-type (111) InSb and n-type (111) InAs surfaces irradiated with similar to 80 fs near-infrared laser pulses are investigated. The azimuthal angle dependence shows that the contribution of the difference-frequency mixing (DFM) is not dominant for both materials at the excitation density of similar to 1 GW/cm(2). At an appropriate azimuthal angle, the radiation due to DFM is excluded from the total THz radiation and the temperature dependence of THz radiation due to the surge current is observed. The increase of THz radiation with decrease of the temperature is found to be much more pronounced for InSb than for InAs. The different temperature dependence can be attributed to the different radiation mechanisms dominant for both materials. Especially, the temperature dependence of the THz radiation from InSb is well explained by the photoDember effect.

  • Generation of coherent terahertz radiation by photomixing of dual-mode lasers

    M Tani, P Gu, M Hyodo, K Sakai, T Hidaka

    OPTICAL AND QUANTUM ELECTRONICS ( KLUWER ACADEMIC PUBL )  32 ( 4-5 ) 503 - 520   2000.05  [Refereed]

     View Summary

    We have reviewed and discussed the generation of continuous-wave terahertz radiation by the photomixing of dual-mode lasers, which includes a multi-mode laser diode (LD), a dual-mode microchip laser, a monolithic dual-mode DBR LD, and a widely tunable dual-mode external cavity LD. It is demonstrated by several experiments that the beat frequency of a dual-mode laser is more stable than the original laser modes because of the common-mode rejection effect. We also suggest a novel scheme by which the optical beat is stabilized to less than 1 kHz and its frequency can be precisely determined as well.

  • Terahertz radiation from LO phonon-plasmon coupling modes in InSb film

    P Gu, M Tani, K Sakai, TR Yang

    2000 25TH INTERNATIONAL CONFERENCE ON INFRARED AND MILLIMETER WAVES CONFERENCE DIGEST ( IEEE )    67 - 68   2000  [Refereed]

  • Generation of cw-terahertz radiation using a two-longitudinal-mode laser diode

    P Gu, M Tani, M Hyodo, K Sakai, T Hidaka

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS ( JAPAN J APPLIED PHYSICS )  37 ( 8B ) L976 - L978   1998.08  [Refereed]

     View Summary

    Coherent cw-terahertz (THz) radiation has been generated by photomixing with a photoconductive antenna fabricated on a low-temperature-grown (LTG) GaAs film using a two-longitudinal-mode distributed Bragg reflector (DBR) laser diode (LD). The frequency of the emitted radiation corresponds to the difference frequency between the two modes of the LD. The linewidth of the radiation is much narrower than that of each laser mode oscillating in the same cavity due to the common-mode rejection effect between the two modes oscillating in the same cavity. This property of the two-mode LD, as well as its compactness and ease of optical alignment, make the device promising as an excitation laser source for photomixing.

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Misc

  • Terahertz radiation from semiconductor surfaces

    P Gu, M Tani

    TERAHERTZ OPTOELECTRONICS ( SPRINGER-VERLAG BERLIN )  97   63 - 97   2005

     View Summary

    In this chapter, terahertz radiation from semiconductor surfaces by excitation of femtosecond laser pulses is discussed with special attention, paid to the influence of lattice vibrations and plasma oscillations in semiconductors. The effect of dielectric dispersion near the optical-phonon resonance, the coupling of the THz electrical transient with longitudinal optical phonons and semiconductor plasmons is considered.

  • Study of terahertz radiation from InAs and InSb

    P Gu, M Tani, S Kono, K Sakai, XC Zhang

    JOURNAL OF APPLIED PHYSICS ( AMER INST PHYSICS )  91 ( 9 ) 5533 - 5537   2002.05

     View Summary

    Terahertz radiation from InSb and InAS, which are typical narrow band-gap semiconductors, was investigated using time-resolved THz emission measurements. When we compared between the polarity of the THz waveforms of these narrow band-gap semiconductors with that of InP, which is a wide bandgap semiconductor, we concluded that the ultrafast buildup of the photo-Dember field is the main mechanism for the emission of THz radiation in both InAs and InSb. The emission efficiency of InSb is approximately one-hundredth of that of InAs, although the electron mobility in InSb is higher than in InAs. Wavelength-dependent measurements implied that the anomalously low THz emission efficiency of InSb might be due to a reduction in transient mobility resulting from the scattering of electrons into the low-mobility L valley. (C) 2002 American Institute of Physics.

    DOI

  • Study of terahertz radiation from InAs and InSb

    P Gu, M Tani, S Kono, K Sakai, XC Zhang

    JOURNAL OF APPLIED PHYSICS ( AMER INST PHYSICS )  91 ( 9 ) 5533 - 5537   2002.05

     View Summary

    Terahertz radiation from InSb and InAS, which are typical narrow band-gap semiconductors, was investigated using time-resolved THz emission measurements. When we compared between the polarity of the THz waveforms of these narrow band-gap semiconductors with that of InP, which is a wide bandgap semiconductor, we concluded that the ultrafast buildup of the photo-Dember field is the main mechanism for the emission of THz radiation in both InAs and InSb. The emission efficiency of InSb is approximately one-hundredth of that of InAs, although the electron mobility in InSb is higher than in InAs. Wavelength-dependent measurements implied that the anomalously low THz emission efficiency of InSb might be due to a reduction in transient mobility resulting from the scattering of electrons into the low-mobility L valley. (C) 2002 American Institute of Physics.

    DOI

  • 24pWG-3 THz wave generation in the photonic crystal cavity by difference frequency mixing

    Kondo H., Ishibashi D., Kitahara H., Wada TaKeda. M., Tani M., Iida M., Sakai K., Gu Ping

    Meeting abstracts of the Physical Society of Japan ( The Physical Society of Japan (JPS) )  57 ( 1 ) 666 - 666   2002.03

  • Detection of terahertz radiation from Longitudinal optical phonon-plasmon coupling mode in Insb tilm using an ultrabroadband phortocond antenna Study of Terahertz Radiation from InAs and Insb

    Journal of Applied Physics   91, 5533-5537   2002

  • Detection of terahertz radiation from Longitudinal optical phonon-plasmon coupling mode in Insb tilm using an ultrabroadband phortocond antenna Study of Terahertz Radiation from InAs and Insb

    Applied Physics Letters   77, 1798-1800   2000

    DOI

  • Generation of CW terahertz radiation by photomixing

    SAKAI Kiyomi, GU Ping, MATSUURA Shuji

    應用物理   68 ( 12 ) 1392 - 1393   1999.12

  • Generation of coherent cw-terahertz radiation using a tunable dual-wavelength external cavity laser diode

    P Gu, F Chang, M Tani, K Sakai, CL Pan

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS ( JAPAN J APPLIED PHYSICS )  38 ( 11A ) L1246 - L1248   1999.11

     View Summary

    A tunable dual-wavelength external cavity laser diode (2-lambda-ECL) was used to generate tunable coherent cw-terahertz (THz) radiation by photomixing in a biased photoconductive antenna fabricated on a low-temperature-grown (LTG)-GaAs film. The 2-lambda-ECL oscillated at the two output modes simultaneously with a frequency separation from 250 GHz to 2.1 THz in the same cavity. We demonstrated that the frequency of the emitted THz radiation corresponded to the difference frequency between the two modes of the diode laser. The tunable 2-lambda-ECL, due to its compact design and ease of optical alignment, is a promising laser source for the generation of tunable cw-THz radiation by photomixing.

    DOI

  • Generation of Coherent Cw-Terahertz Radiation Using a Tunable Dual-Wavelength External cavity Laser Diode

    Japan. J. Appl. Phys.   38, L1246-L1248   1999

    DOI

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    2008.04
    -
    2009.03

    ハルビン工業大学

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    国際交流事業

    国際会議の招待参加,相手国:中国

  • 共同研究

    2007.04
    -
    2008.03

    ハルビン工業大学

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    国際交流事業

    実験設備の立ち上げの助言,相手国:中国

  • 明和中学校

    2007.04

    その他

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    小・中・高校生を対象とした学部体験入学・出張講座等

    出張授業

  • 海南高校

    2007.04

    その他

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    小・中・高校生を対象とした学部体験入学・出張講座等

    体験授業

  • 共同研究

    2006.04
    -
    2007.03

    ハルビン工業大学

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    国際交流事業

    共同研究の組織の立ち上げ,相手国:中国

  • 明和中学校

    2006.04

    明和中学校

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    公開講座・講演会の企画・講師等

    実験体験

  • 海南高校

    2006.04

    その他

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    小・中・高校生を対象とした学部体験入学・出張講座等

    体験授業

  • 公民館 公開講座

    2005.04

       泉南市樫井

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    公開講座・講演会の企画・講師等

    実験・観察・工作

  • 海南高校 

    2005.04

    その他

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    小・中・高校生を対象とした学部体験入学・出張講座等

    出張授業

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Course for renewal of teaching license, teacher-librarian course, etc. (contracted business)

  • 2021  【選択】物理学(光、熱分野)(教員免許状更新講習)

  • 2020  【選択】物理学(光、熱分野)(最小催行人員未満のため開講中止)(教員免許更新講習)

Committee member history in academic associations, government agencies, municipalities, etc.

  • 評議員

    2022.04
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    Now
     

    日本理科教育学会近畿支部

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    学協会、政府、自治体等の公的委員

    学協会、政府、自治体等の公的委員,任期:2

  • 評議員

    2021.04
    -
    2022.03
     

    日本理科教育学会近畿支部

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    学協会、政府、自治体等の公的委員

    学協会、政府、自治体等の公的委員,任期:2

  • 理事

    2020.04
    -
    2021.03
     

    日本物理教育学会近畿支部

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    学協会、政府、自治体等の公的委員

    学協会、政府、自治体等の公的委員,任期:2

  • 理事

    2019.04
    -
    2020.03
     

    日本物理教育学会近畿支部

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    学協会、政府、自治体等の公的委員

    学協会、政府、自治体等の公的委員,任期:2

  • 理事

    2018.04
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    2019.03
     

    日本物理教育学会近畿支部

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    学協会、政府、自治体等の公的委員

    学協会、政府、自治体等の公的委員,任期:2

  • 理事

    2017.07
    -
    2020.03
     

    りんくう国際医療通訳翻訳協会

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    国や地方自治体、他大学・研究機関等での委員

    理事,任期:2017年7月~2019年

  • 理事

    2017.04
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    2019.03
     

    日本物理教育学会近畿支部

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    学協会、政府、自治体等の公的委員

    学協会、政府、自治体等の公的委員,任期:2

  • 教育担当

    2008.04
    -
    2010.03
     

    田尻町

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    国や地方自治体、他大学・研究機関等での委員

    教育担当,任期:2年

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Other Social Activities

  • 在日本中国黒龍江省同郷会関西支部 

    2020.08
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    事務局

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    教育 文化交流

    同郷会の親睦や助け合い特に教育に関する助言と相談

  • 在日本中国黒龍江省同郷会関西支部 

    2020.08
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    Now

    事務局

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    教育 文化交流

    同郷会の親睦や助け合い特に教育に関する助言と相談

  • 在日本中国黒龍江省同郷会関西支部 

    2020.08
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    Now

    事務局

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    教育 文化交流

    同郷会の親睦や助け合い特に教育に関する助言と相談

  • 西日本豪雨チャリティー募金

    2018.08

    その他

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    社会との連携を推進する活動

    出演

  • 医療通訳翻訳協会

    2018.04
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    2019.03

    その他

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    ボランティア活動等

    中国語担当

  • 医療通訳翻訳協会

    2017.04
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    2018.03

    その他

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    ボランティア活動等

    中国語担当

  • 2015年度の青少年のための科学の祭典---おもしろ科学まつり---和歌山大会

    2016.04
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    2017.03

    その他

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    社会との連携を推進する活動

    実行委員長

  • 医療通訳翻訳協会

    2016.04
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    2017.03

    その他

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    ボランティア活動等

    中国語担当

  • 2015年度の青少年のための科学の祭典---おもしろ科学まつり---和歌山大会

    2015.04
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    2016.03

    その他

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    社会との連携を推進する活動

    実行委員会の事務局長

  • 医療通訳翻訳協会

    2015.04
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    2016.03

    その他

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    ボランティア活動等

    中国語担当

  • 医療通訳翻訳協会 

    2013.04
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    2014.03

    その他

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    ボランティア活動等

    中国語担当理事

  • 医療通訳翻訳協会 

    2012.04
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    2013.03

    その他

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    ボランティア活動等

    通訳担当理事

  • 医療通訳翻訳協会 

    2011.04
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    2012.03

    その他

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    ボランティア活動等

    通訳担当理事

  • 大阪府泉南郡田尻町新総合計画の委員

    2009.04
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    2010.03

    その他

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    ボランティア活動等

    教育策担当

  • 大阪府泉南郡田尻町新総合計画の委員

    2008.04
    -
    2009.03

    その他

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    ボランティア活動等

    教育策担当

  • さきとり研究

    2008.04
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    2009.03

    その他

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    産業界、行政諸機関等と行った共同研究、新技術創出、コンサルティング等

    株式会社ABsizeとナノ粒子の作製の研究,実施者:和歌山大学 

  • さきとり研究

    2007.04
    -
    2008.03

    その他

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    産業界、行政諸機関等と行った共同研究、新技術創出、コンサルティング等

    株式会社ABsizeとナノ粒子の作製の研究,実施者:和歌山大学 

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