Education
-
2001-2005
Kyoto Institute of Technology Graduate School of Science and Technology 工芸科学研究科博士後期課程
Degree
-
博士(学術)
Academic & Professional Experience
-
2016.10-Now
Wakayama University Graduate School of Systems Engineering 准教授
-
2009.06-2016.09
Japan Advanced Institute of Science and Technology マテリアルサイエンス研究科 助教
-
2007.04-2009.05
京都大学大学院 工学研究科 博士研究員
-
2005.04-2007.03
Kyoto Institute of Technology Graduate School of Science and Technology 博士研究員
Research Areas
-
Nanotechnology/Materials / Chemical biology
-
Life sciences / Bioorganic chemistry
Classes (including Experimental Classes, Seminars, Graduation Thesis Guidance, Graduation Research, and Topical Research)
-
2023 Scientific and Technical English B Specialized Subjects
-
2023 Graduation Research Specialized Subjects
-
2023 Experiments in Applied Chemistry Specialized Subjects
-
2023 Advanced Lectures in Chemistry Specialized Subjects
-
2023 Experiments in Chemistry Ⅲ Specialized Subjects
-
2023 Practices in Chemistry Specialized Subjects
-
2023 Experiments in Chemistry IV Specialized Subjects
-
2023 Practices in Chemoinformatics Specialized Subjects
-
2023 Basic Life Science Specialized Subjects
-
2023 Life Science Specialized Subjects
-
2022 Graduation Research Specialized Subjects
-
2022 Graduation Research Specialized Subjects
-
2022 Experiments in Material Science andChemistry C Specialized Subjects
-
2022 Seminar in Material Science and Chemistry ⅡA Specialized Subjects
-
2022 Seminar in Material Science and Chemistry ⅠA Specialized Subjects
-
2022 Life Science Specialized Subjects
-
2022 Practices in Chemoinformatics Specialized Subjects
-
2022 Basic Life Science Specialized Subjects
-
2022 Scientific and Technical English B Specialized Subjects
-
2022 Advanced Lectures in Chemistry Specialized Subjects
-
2022 Experiments in Chemistry IV Specialized Subjects
-
2022 Experiments in Chemistry Ⅲ Specialized Subjects
-
2022 Practices in Chemistry Specialized Subjects
-
2022 Experiments in Applied Chemistry Specialized Subjects
-
2022 Nanotechnologies Ⅱ Specialized Subjects
-
2022 Introductory Seminar in Systems Engineering Specialized Subjects
-
2021 Graduation Research Specialized Subjects
-
2021 Experiments in Material Science andChemistry C Specialized Subjects
-
2021 Seminar in Material Science and Chemistry ⅡA Specialized Subjects
-
2021 Seminar in Material Science and Chemistry ⅠA Specialized Subjects
-
2021 Life Science Specialized Subjects
-
2021 Experiments in Chemistry Ⅲ Specialized Subjects
-
2021 Advanced Lectures in Chemistry Specialized Subjects
-
2021 Practices in Chemistry Specialized Subjects
-
2021 Experiments in Applied Chemistry Specialized Subjects
-
2021 Graduation Research Specialized Subjects
-
2021 Graduation Research Specialized Subjects
-
2021 Practices in Chemoinformatics Specialized Subjects
-
2021 Basic Life Science Specialized Subjects
-
2021 Scientific and Technical English B Specialized Subjects
-
2021 Experiments in Chemistry IV Specialized Subjects
-
2021 Nanotechnologies Ⅱ Specialized Subjects
-
2020 Graduation Research Specialized Subjects
-
2020 Graduation Research Specialized Subjects
-
2020 Introductory Seminar in Systems Engineering Specialized Subjects
-
2020 Experiments in Chemistry IV Specialized Subjects
-
2020 Practices in Chemoinformatics Specialized Subjects
-
2020 Experiments in Chemistry Ⅲ Specialized Subjects
-
2020 Life Science Specialized Subjects
-
2020 Basic Life Science Specialized Subjects
-
2020 Scientific and Technical English B Specialized Subjects
-
2020 Experiments in Applied Chemistry Specialized Subjects
-
2020 Advanced Lectures in Chemistry Specialized Subjects
-
2020 Seminar in Material Science and Chemistry ⅡA Specialized Subjects
-
2020 Seminar in Material Science and Chemistry ⅠA Specialized Subjects
-
2020 Practices in Chemistry Specialized Subjects
-
2020 Nanotechnologies Ⅱ Specialized Subjects
-
2020 Experiments in Material Science andChemistry C Specialized Subjects
-
2019 Practices in Chemoinformatics Specialized Subjects
-
2019 Scientific and Technical English B Specialized Subjects
-
2019 Experiments in Material Science and Chemistry Specialized Subjects
-
2019 Experiments in Applied Chemistry Specialized Subjects
-
2019 Advanced Lectures in Chemistry Specialized Subjects
-
2019 Seminar in Material Science and Chemistry ⅡA Specialized Subjects
-
2019 Seminar in Material Science and Chemistry ⅠA Specialized Subjects
-
2019 Practices in Chemistry Specialized Subjects
-
2019 Nanotechnologies Ⅱ Specialized Subjects
-
2019 Nanotechnologies Ⅰ Specialized Subjects
-
2019 Experiments in Material Science andChemistry B Specialized Subjects
-
2019 Experiments in Material Science andChemistry C Specialized Subjects
-
2019 Experiments in Chemistry Ⅲ Specialized Subjects
-
2019 Life Science Specialized Subjects
-
2019 Basic Life Science Specialized Subjects
-
2018 Life Science Specialized Subjects
-
2018 Basic Life Science Specialized Subjects
-
2018 Scientific and Technical English B Specialized Subjects
-
2018 Experiments in Material Science and Chemistry Specialized Subjects
-
2018 Experiments in Applied Chemistry Specialized Subjects
-
2018 Advanced Lectures in Chemistry Specialized Subjects
-
2018 Seminar in Material Science and Chemistry ⅡA Specialized Subjects
-
2018 Seminar in Material Science and Chemistry ⅠA Specialized Subjects
-
2018 Practices in Chemistry Specialized Subjects
-
2018 Nanotechnologies Ⅱ Specialized Subjects
-
2018 Experiments in Material Science andChemistry C Specialized Subjects
-
2017 Advanced Lectures in Chemistry Specialized Subjects
-
2017 Experiments in Applied Chemistry Specialized Subjects
-
2017 Life Science Specialized Subjects
-
2017 Seminar in Material Science and Chemistry ⅡA Specialized Subjects
-
2017 Practices in Chemistry Specialized Subjects
-
2017 Nanotechnologies Ⅰ Specialized Subjects
-
2017 Experiments in Material Science andChemistry C Specialized Subjects
-
2017 Experiments in Material Science andChemistry B Specialized Subjects
-
2017 Basic Life Science Specialized Subjects
-
2017 Experiments in Material Science and Chemistry Specialized Subjects
-
2017 Introductory Seminar in Systems Engineering Specialized Subjects
-
2017 Seminar in Material Science and Chemistry ⅠA Specialized Subjects
-
2017 Nanotechnologies Ⅱ Specialized Subjects
Classes
-
2023 Systems Engineering SeminarⅠA Master's Course
-
2023 Systems Engineering SeminarⅠB Master's Course
-
2023 Systems Engineering SeminarⅡA Master's Course
-
2023 Systems Engineering SeminarⅡB Master's Course
-
2023 Introduction to Chemical Biology Master's Course
-
2023 Systems Engineering Project SeminarⅠA Master's Course
-
2023 Systems Engineering Project SeminarⅠB Master's Course
-
2023 Systems Engineering Project SeminarⅡA Master's Course
-
2023 Systems Engineering Project SeminarⅡB Master's Course
-
2023 Systems Engineering Advanced Seminar Ⅰ Doctoral Course
-
2023 Systems Engineering Advanced Seminar Ⅰ Doctoral Course
-
2023 Systems Engineering Advanced Seminar Ⅱ Doctoral Course
-
2023 Systems Engineering Advanced Seminar Ⅱ Doctoral Course
-
2023 Systems Engineering Advanced Research Doctoral Course
-
2023 Systems Engineering Advanced Research Doctoral Course
-
2023 Systems Engineering Global Seminar Ⅰ Doctoral Course
-
2023 Systems Engineering Global Seminar Ⅰ Doctoral Course
-
2023 Systems Engineering Global Seminar Ⅱ Doctoral Course
-
2023 Systems Engineering Global Seminar Ⅱ Doctoral Course
-
2022 Systems Engineering Global Seminar Ⅱ Doctoral Course
-
2022 Systems Engineering Global Seminar Ⅰ Doctoral Course
-
2022 Systems Engineering Advanced Research Doctoral Course
-
2022 Systems Engineering Advanced Seminar Ⅱ Doctoral Course
-
2022 Systems Engineering Advanced Seminar Ⅰ Doctoral Course
-
2022 Systems Engineering Project SeminarⅡB Master's Course
-
2022 Systems Engineering Project SeminarⅡA Master's Course
-
2022 Systems Engineering Project SeminarⅠB Master's Course
-
2022 Systems Engineering Project SeminarⅠA Master's Course
-
2022 Introduction to Chemical Biology Master's Course
-
2022 Systems Engineering SeminarⅡB Master's Course
-
2022 Systems Engineering SeminarⅡA Master's Course
-
2022 Systems Engineering SeminarⅠB Master's Course
-
2022 Systems Engineering SeminarⅠA Master's Course
-
2021 Systems Engineering Global Seminar Ⅱ Doctoral Course
-
2021 Systems Engineering Global Seminar Ⅰ Doctoral Course
-
2021 Systems Engineering Advanced Research Doctoral Course
-
2021 Systems Engineering Advanced Seminar Ⅱ Doctoral Course
-
2021 Systems Engineering Advanced Seminar Ⅰ Doctoral Course
-
2021 Systems Engineering Project SeminarⅡB Master's Course
-
2021 Systems Engineering Project SeminarⅡA Master's Course
-
2021 Systems Engineering Project SeminarⅠB Master's Course
-
2021 Systems Engineering Project SeminarⅠA Master's Course
-
2021 Introduction to Chemical Biology Master's Course
-
2021 Systems Engineering SeminarⅡB Master's Course
-
2021 Systems Engineering SeminarⅡA Master's Course
-
2021 Systems Engineering SeminarⅠB Master's Course
-
2021 Systems Engineering SeminarⅠA Master's Course
-
2020 Systems Engineering Global Seminar Ⅱ Doctoral Course
-
2020 Systems Engineering Global Seminar Ⅰ Doctoral Course
-
2020 Systems Engineering Advanced Research Doctoral Course
-
2020 Systems Engineering Advanced Seminar Ⅱ Doctoral Course
-
2020 Systems Engineering Advanced Seminar Ⅰ Doctoral Course
-
2020 Systems Engineering Project SeminarⅡB Master's Course
-
2020 Systems Engineering Project SeminarⅡA Master's Course
-
2020 Systems Engineering Project SeminarⅠB Master's Course
-
2020 Systems Engineering Project SeminarⅠA Master's Course
-
2020 Introduction to Chemical Biology Master's Course
-
2020 Systems Engineering SeminarⅡB Master's Course
-
2020 Systems Engineering SeminarⅡA Master's Course
-
2020 Systems Engineering SeminarⅠB Master's Course
-
2020 Systems Engineering SeminarⅠA Master's Course
-
2019 Introduction to Chemical Biology Master's Course
-
2019 Systems Engineering Advanced Seminar Ⅱ Doctoral Course
-
2019 Systems Engineering Advanced Seminar Ⅱ Doctoral Course
-
2019 Systems Engineering Advanced Seminar Ⅰ Doctoral Course
-
2019 Systems Engineering Advanced Seminar Ⅰ Doctoral Course
-
2019 Systems Engineering Advanced Research Doctoral Course
-
2019 Systems Engineering Advanced Research Doctoral Course
-
2019 Systems Engineering SeminarⅡB Master's Course
-
2019 Systems Engineering SeminarⅡA Master's Course
-
2019 Systems Engineering SeminarⅠB Master's Course
-
2019 Systems Engineering SeminarⅠA Master's Course
-
2019 Systems Engineering Project SeminarⅡB Master's Course
-
2019 Systems Engineering Project SeminarⅠB Master's Course
-
2019 Systems Engineering Project SeminarⅠA Master's Course
-
2018 Systems Engineering Advanced Research Doctoral Course
-
2018 Systems Engineering Advanced Research Doctoral Course
-
2018 Systems Engineering Advanced Seminar Ⅰ Doctoral Course
-
2018 Systems Engineering Advanced Seminar Ⅰ Doctoral Course
-
2018 Systems Engineering Project SeminarⅡB Master's Course
-
2018 Systems Engineering Project SeminarⅡA Master's Course
-
2018 Systems Engineering Project SeminarⅠB Master's Course
-
2018 Systems Engineering Project SeminarⅠA Master's Course
-
2018 Systems Engineering SeminarⅡB Master's Course
-
2018 Systems Engineering SeminarⅡA Master's Course
-
2018 Systems Engineering SeminarⅠB Master's Course
-
2018 Systems Engineering SeminarⅠA Master's Course
-
2017 Systems Engineering Advanced Research Doctoral Course
-
2017 Systems Engineering Advanced Research Doctoral Course
-
2017 Systems Engineering Advanced Seminar Ⅰ Doctoral Course
-
2017 Systems Engineering Project SeminarⅠA Master's Course
-
2017 Systems Engineering SeminarⅡB Master's Course
-
2017 Systems Engineering SeminarⅡA Master's Course
-
2017 Systems Engineering SeminarⅠB Master's Course
Papers and Awards Received Related to Improving Education
-
2019 グッドレクチャー賞 和歌山大学 システム工学部長 Domestic
Published Papers
-
Tripodal Quinone-Cyanine G-Quadruplex Ligands as Novel Photosensitizers on Photoinduced Cancer Cell Death
Junya Muramoto, Takashi Sakamoto (Part: Last author, Corresponding author )
Molecules 2024.10 [Refereed] [Invited]
-
Near-Infrared Fluorescent Switch-On Probe for Guanine-Quadruplex Imaging with Extremely Large Stokes Shift
Yuka Muraoka, Junya Muramoto, Yu Yasuhara, Mayuko Kawatake, Takashi Sakamoto (Part: Last author, Corresponding author )
Analytical Chemistry ( American Chemical Society (ACS) ) 95 ( 47 ) 17162 - 17165 2023.11 [Refereed]
-
Tripodal Quinone-cyanine Fluorescent Dye as a Tool for Analyzing Structural Dynamics of DNA Guanine-quadruplex
Takashi Sakamoto, Zehui Yu (Part: Lead author, Corresponding author )
Chemistry Letters ( The Chemical Society of Japan ) 51 ( 12 ) 1139 - 1142 2022.12 [Refereed]
-
Dual-Color Fluorescence Switch-On Probe for Imaging G-Quadruplex and Double-Stranded DNA in Living Cells
Takashi Sakamoto, Zehui Yu, Yuto Otani (Part: Lead author, Corresponding author )
Analytical Chemistry ( American Chemical Society ({ACS}) ) 94 ( 10 ) 4269 - 4276 2022.03 [Refereed]
-
Simultaneous Amino Acid Analysis Based on <sup>19</sup>F NMR Using a Modified OPA-Derivatization Method
Takashi Sakamoto, Zhiyong Qiu, Miyu Inagaki, Kenzo Fujimoto (Part: Lead author, Corresponding author )
Analytical Chemistry ( American Chemical Society (ACS) ) 92 ( 2 ) 1669 - 1673 2019.12 [Refereed]
-
Takashi Sakamoto, Rikuto Yamada
ChemBioChem ( Wiley ) 20 ( 10 ) 1206 - 1206 2019.05
-
Photo-cross-linkable artificial nucleic acid: Synthesis and properties of 3-cyanovinylcarbazole-modified nucleic acids and its photo-induced gene-silencing activity in cells
Takashi Sakamoto, Kenzo Fujimoto (Part: Lead author )
Synthesis of Therapeutic Oligonucleotides 171 - 186 2018.12 [Refereed]
-
Disassembly-driven signal turn-on probes for bimodal detection of DNA with 19F NMR and fluorescence
Takashi Sakamoto, Daisaku Hasegawa, Kenzo Fujimoto (Part: Lead author, Corresponding author )
Organic & Biomolecular Chemistry ( Royal Society of Chemistry ({RSC}) ) 2018 [Refereed]
-
Effect of nucleobase change on cytosine deamination through DNA photo-cross-linking reaction via 3-cyanovinylcarbazole nucleoside.
Sethi S, Ooe M, Sakamoto T, Fujimoto K
2017.04 [Refereed]
-
Characterization of human telomere RNA G-quadruplex structures in vitro and in living cells using 19F NMR spectroscopy.
Bao HL, Ishizuka T, Sakamoto T, Fujimoto K, Uechi T, Kenmochi N, Xu Y
2017.02 [Refereed]
-
UVA-responsive Anticancer Prodrugs Based on Photoinduced Electron Injection into Oligonucleotide Having 5-Halouracils
Fujimoto, Kenzo, Furusawa, Mirei, Nakamura, Shigetaka, Sakamoto, Takashi (Part: Last author )
Chemistry Letters ( The Chemical Society of Japan ) 45 ( 9 ) 1078 - 1080 2016.06 [Refereed]
-
Simultaneous detection of single-nucleotide polymorphisms in a DNA bulge structure using a fluorine-modified bisbenzimide derivative
Sakamoto, Takashi, Hasegawa, Daisaku, Fujimoto, Kenzo (Part: Lead author, Corresponding author )
Analyst ( Royal Society of Chemistry ) 141 ( 4 ) 1214 - 1217 2016.02 [Refereed]
-
Photo-Cross-Linking Reaction in Nucleic Acids: Chemistry and Applications
Sakamoto, Takashi, Fujimoto, Kenzo (Part: Lead author )
Modified Nucleic Acids ( Springer ) 145 - 157 2016 [Refereed]
-
RNA fluorescence in situ hybridization using 3-cyanovinylcarbazole modified oligodeoxyribonucleotides as photo-cross-linkable probes
Fujimoto, Kenzo, Toyosato, Kei, Nakamura, Shigetaka, Sakamoto, Takashi (Part: Last author )
Bioorganic & Medicinal Chemistry Letters ( Pergamon ) 26 ( 21 ) 5312 - 5314 2016 [Refereed]
-
Critical effect of base pairing of target pyrimidine on the interstrand photo-cross-linking of DNA via 3-cyanovinylcarbazole nucleoside
Sakamoto, Takashi, Ooe, Minako, Fujimoto, Kenzo (Part: Lead author )
Bioconjugate chemistry ( ACS Publications ) 26 ( 8 ) 1475 - 1478 2015 [Refereed]
-
DNA photo-cross-linking using 3-cyanovinylcarbazole modified oligonucleotide with threoninol linker
Sakamoto, Takashi, Tanaka, Yuya, Fujimoto, Kenzo (Part: Lead author )
Organic letters ( ACS Publications ) 17 ( 4 ) 936 - 939 2015 [Refereed]
-
Changing blue fluorescent protein to green fluorescent protein using chemical RNA editing as a novel strategy in genetic restoration
Vu, Luyen T, Nguyen, Thanh TK, Alam, Shafiul, Sakamoto, Takashi, Fujimoto, Kenzo, Suzuki, Hitoshi, Tsukahara, Toshifumi
Chemical biology & drug design ( Wiley Online Library ) 86 ( 5 ) 1242 - 1252 2015 [Refereed]
-
Fluorine-modified bisbenzimide derivative as a molecular probe for bimodal and simultaneous detection of DNAs by 19 F NMR and fluorescence
Sakamoto, Takashi, Hasegawa, Daisaku, Fujimoto, Kenzo (Part: Lead author, Corresponding author )
Chemical Communications ( Royal Society of Chemistry ) 51 ( 42 ) 8749 - 8752 2015 [Refereed]
-
Short oligonucleotide prodrug having 5-fluoro and 5-iodouracil inhibits the proliferation of cancer cells in a photo-responsive manner
Fujimoto, Kenzo, Takematsu, Yu-ki, Shigeno, Atsuo, Furusawa, Mirei, Sakamoto, Takashi (Part: Last author )
Bioorganic & medicinal chemistry letters ( Elsevier ) 24 ( 16 ) 3736 - 3738 2014 [Refereed]
-
Photo-regulation of constitutive gene expression in living cells by using ultrafast photo-cross-linking oligonucleotides
Sakamoto, Takashi, Shigeno, Atsuo, Ohtaki, Yuichi, Fujimoto, Kenzo (Part: Lead author )
Biomaterials Science ( Royal Society of Chemistry ) 2 ( 9 ) 1154 - 1157 2014 [Refereed]
-
Details of the ultrafast DNA photo-cross-linking reaction of 3-cyanovinylcarbazole nucleoside: cis--trans isomeric effect and the application for SNP-based genotyping
Fujimoto, Kenzo, Yamada, Asuka, Yoshimura, Yoshinaga, Tsukaguchi, Tadashi, Sakamoto, Takashi (Part: Last author )
Journal of the American Chemical Society ( ACS Publications ) 135 ( 43 ) 16161 - 16167 2013 [Refereed]
-
Diamine Derivatives Accelerate Photochemical C→ U Transition in DNA Double Strand
Fujimoto, Kenzo, Futamura, Daiki, Sakamoto, Takashi (Part: Last author )
Chemistry Letters ( The Chemical Society of Japan ) 42 ( 3 ) 289 - 291 2013 [Refereed]
-
Quick and reversible photocrosslinking reaction of 3-cyanovinylcarbazole nucleoside in a DNA triplex
Fujimoto, Kenzo, Yoshinaga, Hiroki, Yoshio, Yasumasa, Sakamoto, Takashi (Part: Last author )
Organic & biomolecular chemistry ( Royal Society of Chemistry ) 11 ( 31 ) 5065 - 5068 2013 [Refereed]
-
Quick, selective and reversible photocrosslinking reaction between 5-methylcytosine and 3-cyanovinylcarbazole in DNA double strand
Fujimo, Kenzo, Konishi-Hiratsuka, Kaoru, Sakamoto, Takashi (Part: Last author )
International journal of molecular sciences ( Multidisciplinary Digital Publishing Institute ) 14 ( 3 ) 5765 - 5774 2013 [Refereed]
-
Geometric Effect on the Photocrosslinking Reaction between 3-Cyanovinylcarbazole Nucleoside and Pyrimidine Base in DNA/RNA Heteroduplex
Fujimoto, Kenzo, Kishi, Satomi, Sakamoto, Takashi (Part: Last author )
Photochemistry and photobiology ( Wiley Online Library ) 89 ( 5 ) 1095 - 1099 2013 [Refereed]
-
Development about photochemical DNA and RNA crosslinking via 3-cyanovinylcarbazole
Satomi Kishi, Daiki Futamura, Kaoru Hiratsuka, Takashi Sakamoto, Kenzo Fujimoto
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY ( AMER CHEMICAL SOC ) 243 2012.03 [Refereed]
-
Regulation of gene expression by photocrosslinking oligonucleotide containing of carbazole
Atsuo Shigeno, Sakamoto Takashi, Kenzo Fujimoto
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY ( AMER CHEMICAL SOC ) 243 2012.03 [Refereed]
-
Quick regulation of mRNA functions by a few seconds of photoirradiation
Shigeno, Atsuo, Sakamoto, Takashi, Yoshimura, Yoshinaga, Fujimoto, Kenzo
Organic & biomolecular chemistry ( Royal Society of Chemistry ) 10 ( 38 ) 7820 - 7825 2012 [Refereed]
-
Specific and reversible photochemical labeling of plasmid DNA using photoresponsive oligonucleotides containing 3-cyanovinylcarbazole
Fujimoto, Kenzo, Hiratsuka-Konishi, Kaoru, Sakamoto, Takashi, Ohtake, Tomoko, Shinohara, Ken-ichi, Yoshimura, Yoshinaga
Molecular BioSystems ( Royal Society of Chemistry ) 8 ( 2 ) 491 - 494 2012 [Refereed]
-
Signal turn-on probe for nucleic acid detection based on 19 F nuclear magnetic resonance
Sakamoto, Takashi, Shimizu, Yu-ki, Sasaki, Jun, Hayakawa, Hikaru, Fujimoto, Kenzo (Part: Lead author )
Bioorganic & medicinal chemistry letters ( Elsevier ) 21 ( 1 ) 303 - 306 2011 [Refereed]
-
5-Methylcytosine selective photoligation using photoresponsive oligonucleotides containing various 5-vinyl-2′-deoxyuridines having an aromatic group
Sakamoto, Takashi, Ami, Takehiro, Fujimoto, Kenzo (Part: Lead author )
Chemistry Letters ( The Chemical Society of Japan ) 41 ( 1 ) 47 - 49 2011 [Refereed]
-
Development of a Potassium Ion Sensor for 19F Magnetic Resonance Chemical Shift Imaging Based on Fluorine-labeled Thrombin Aptamer
Sakamoto, Takashi, Hayakawa, Hikaru, Fujimoto, Kenzo (Part: Lead author )
Chemistry Letters ( The Chemical Society of Japan ) 40 ( 7 ) 720 - 721 2011 [Refereed]
-
1P346 DNA computing based on photochemical DNA manipulation(Miscellaneous topics,The 48th Annual Meeting of the Biophysical Society of Japan)
Ogasawara Shinji, Sakamoto Takashi, Nakamura Shigetaka, Fujimoto Kenzo
Seibutsu Butsuri ( The Biophysical Society of Japan General Incorporated Association ) 50 ( 2 ) S81 2010
-
Site-specific photochemical RNA editing
Fujimoto, Kenzo, Konishi-Hiratsuka, Kaoru, Sakamoto, Takashi, Yoshimura, Yoshinaga
Chemical Communications ( Royal Society of Chemistry ) 46 ( 40 ) 7545 - 7547 2010 [Refereed]
-
Site-Specific Cytosine to Uracil Transition by Using Reversible DNA Photo-crosslinking
Fujimoto, Kenzo, Konishi-Hiratsuka, Kaoru, Sakamoto, Takashi, Yoshimura, Yoshinaga
ChemBioChem ( Wiley Online Library ) 11 ( 12 ) 1661 - 1664 2010 [Refereed]
-
Molecular recognition, fluorescence sensing, and biological assay of phosphate anion derivatives using artificial Zn (II)--Dpa complexes
Sakamoto, Takashi, Ojida, Akio, Hamachi, Itaru (Part: Lead author )
Chemical Communications ( Royal Society of Chemistry ) ( 2 ) 141 - 152 2009 [Refereed]
-
Self-assembling nanoprobes that display off/on 19F nuclear magnetic resonance signals for protein detection and imaging
Takaoka, Yousuke, Sakamoto, Takashi, Tsukiji, Shinya, Narazaki, Michiko, Matsuda, Tetsuya, Tochio, Hidehito, Shirakawa, Masahiro, Hamachi, Itaru
Nature chemistry ( Nature Publishing Group ) 1 ( 7 ) 557 - 561 2009 [Refereed]
-
Fluorescent BODIPY-based Zn (II) complex as a molecular probe for selective detection of neurofibrillary tangles in the brains of Alzheimer’s disease patients
Ojida, Akio, Sakamoto, Takashi, Inoue, Masa-aki, Fujishima, Sho-hei, Lippens, Guy, Hamachi, Itaru
Journal of the American Chemical Society ( ACS Publications ) 131 ( 18 ) 6543 - 6548 2009 [Refereed]
-
Real-time fluorescence monitoring of GSK3$β$-catalyzed phosphoryation by use of a BODIPY-based Zn (II)--Dpa chemosensor
Sakamoto, Takashi, Inoue, Masa-aki, Ojida, Akio, Hamachi, Itaru (Part: Lead author )
Bioorganic & medicinal chemistry letters ( Elsevier ) 19 ( 15 ) 4175 - 4177 2009 [Refereed]
-
Microarray-based label-free detection of RNA using bispyrene-modified 2′-O-methyl oligoribonucleotide as capture and detection probe
Sakamoto, Takashi, Kobori, Akio, Murakami, Akira (Part: Lead author )
Bioorganic & medicinal chemistry letters ( Elsevier ) 18 ( 8 ) 2590 - 2593 2008 [Refereed]
-
Transcriptome analysis device based on liquid phase detection by fluorescently labeled nucleic acid probes
Yokokawa, Ryuji, Tamaoki, Soichiro, Sakamoto, Takashi, Murakami, Akira, Sugiyama, Susumu
Biomedical microdevices ( Springer ) 9 ( 6 ) 869 - 875 2007 [Refereed]
-
Real-time monitoring of antibody secretion from B-cells on a microchip stimulated with a minute amount of mitogen
Munaka, Tatsuya, Abe, Hirohisa, Kanai, Masaki, Sakamoto, Takashi, Nakanishi, Hiroaki, Shoji, Shuichi, Kimura, Shinya, Maekawa, Taira, Murakami, Akira
Analyst ( Royal Society of Chemistry ) 132 ( 6 ) 512 - 514 2007 [Refereed]
-
Homogeneous Fluorescence Assays for RNA Diagnosis by Pyrene-Conjugated 2′-O-Methyloligoribonucleotides
Sakamoto, Takashi, Kobori, Akio, Shigezawa, Masako, Amitani, Yasutaka, Higuchi, Maiko, Murakami, Akira (Part: Lead author )
Nucleosides, Nucleotides, and Nucleic Acids ( Taylor \& Francis ) 26 ( 10-12 ) 1659 - 1664 2007 [Refereed]
-
Highly-sensitive detection of immunoreactions by time-resolved fluorescence anisotropy analysis
Takashi Sakamoto, Nobuyuki Fujihara, Akio Kobori, Akira Murakami, Miharu Kishi, Koichi Yamagata
Polymer Preprints, Japan 55 ( 2 ) 4933 2006
-
Properties of novel antisense oligonucleotides containing 2′-O-modified adenosine with a photo-reactive group
Higuchi Maiko, Sakamoto Takashi, Kobori Akio, Murakami Akira
Nucleic Acids Symposium Series 50 ( 1 ) 301 - 2 2006 [Refereed]
-
Solid-phase detection of RNA using bispyrene-modified RNA probe
Sakamoto Takashi, Kobori Akio, Murakami Akira (Part: Lead author )
Nucleic Acids Symposium Series 50 ( 1 ) 215 - 6 2006 [Refereed]
-
Monitoring cellular events in living mast cells stimulated with an extremely small amount of fluid on a microchip
Munaka, Tatsuya, Abe, Hirohisa, Kanai, Masaki, Sakamoto, Takashi, Nakanishi, Hiroaki, Yamaoka, Tetsuji, Shoji, Shuichi, Murakami, Akira
Japanese journal of applied physics ( IOP Publishing ) 45 ( 7L ) L634 2006 [Refereed]
-
Real-time monitoring of antibody secretion from hybridomas on a microchip by time-resolved luminescence anisotropy analysis
Munaka, Tatsuya, Abe, Hirohisa, Kanai, Masaki, Sakamoto, Takashi, Nakanishi, Hiroaki, Yamaoka, Tetsuji, Shoji, Shuichi, Murakami, Akira
Analytical biochemistry ( Elsevier ) 353 ( 1 ) 1 - 6 2006 [Refereed]
-
Development of the cell analysis chip (II)
Tatsuya Munaka, Masaki Kanai, Hirohisa Abe, Hiroaki Nakanishi, Takashi Sakamoto, Akio Kobori, Tetsuji Yamaoka, Shuichi Shoji, Akira Murakami
Polymer Preprints, Japan 54 ( 1 ) 2329 2005 [Refereed]
-
Analytical method for estimation of kinetics of oligonucleotide/RNA hybridization using fluorescence depolarization spectroscopy
Sakamoto, Takashi, Mahara, Atsushi, Iwase, Reiko, Yamaoka, Tetsuji, Murakami, Akira (Part: Lead author )
Analytical biochemistry ( Academic Press ) 340 ( 2 ) 369 - 372 2005 [Refereed]
-
Transcriptome Analyzing Chip Based on Liquid-phase Detection Using Fluorescence Labeled Nucleic Acid Probe
Tamaoki S, Sugiyama S, Sakamoto T, Murakami A
PROCEEDINGS OF THE SENSOR SYMPOSIUM ON SENSORS MICROMACHINES AND APPLIED SYSTEMS 22 270 2005 [Refereed]
-
Evaluation of dynamic features of Escherichia coli 16S ribosomal RNA in homogeneous physiological solution
Sakamoto, Takashi, Mahara, Atsushi, Yamagata, Koichi, Iwase, Reiko, Yamaoka, Tetsuji, Murakami, Akira (Part: Lead author )
Biophysical journal ( Elsevier ) 89 ( 6 ) 4122 - 4128 2005 [Refereed]
-
Luminescence anisotropy-based detection of nucleic acids and proteins using long-lifetime Ru(II) complex as a luminescent label.
Takashi Sakamoto, Atsushi Mahara, Kobori Akio, Tetsuji Yamaoka, Akira Murakami (Part: Lead author )
Nucleic acids symposium series (2004) 49 ( 49 ) 203 - 204 2005 [Refereed]
-
Time-resolved luminescence anisotropy-based detection of immunoglobulin G using long-lifetime Ru (II) complex-labeled protein A
Sakamoto, Takashi, Mahara, Atsushi, Munaka, Tatsuya, Yamagata, Koich, Iwase, Reiko, Yamaoka, Tetsuji, Murakami, Akira (Part: Lead author )
Analytical biochemistry ( Academic Press ) 329 ( 1 ) 142 - 144 2004 [Refereed]
-
Transcriptome analysis using fluorescence-labeled oligonucleotide.
Naohiko Shimada, Atsushi Mahara, Takashi Sakamoto, Tetsuji Yamaoka, Akira Murakami
Nucleic acids symposium series (2004) 48 ( 48 ) 301 - 302 2004 [Refereed]
-
In situ Cell Monitoring on a Microchip using Time-Resolved Fluorescence Anisotropy Analysis
Sakamoto Takashi, Mahara Atsushi, Yamayoshi Asako
Seibutsu Butsuri ( The Biophysical Society of Japan General Incorporated Association ) 43 S222 2003.10 [Refereed]
-
村上 章, 坂本 隆, 馬原 淳
化学と生物 ( Japan Society for Bioscience, Biotechnology, and Agrochemistry ) 41 ( 8 ) 549 - 556 2003.08
-
Detection of acceptor sites for antisense oligonucleotides on native folded RNA by fluorescence-labeled oligonucleotide.
Atsushi Mahara, Takashi Sakamoto, Tatsuya Munaka, Reiko Iwase, Tetsuji Yamaoka, Akira Murakami
Nucleic acids research. Supplement (2001) 3 ( 3 ) 73 - 74 2003 [Refereed]
-
Detection of acceptor sites for antisense oligonucleotides on native folded RNA by fluorescence spectroscopy
Mahara, Atsushi, Iwase, Reiko, Sakamoto, Takashi, Yamaoka, Tetsuji, Yamana, Kazushige, Murakami, Akira
Bioorganic & medicinal chemistry ( Elsevier ) 11 ( 13 ) 2783 - 2790 2003 [Refereed]
-
Bispyrene-conjugated 2'-O-methyloligonucleotide as a highly specific RNA-recognition probe.
Atsushi Mahara, Reiko Iwase, Takashi Sakamoto, Kazushige Yamana, Tetsuji Yamaoka, Akira Murakami
Angewandte Chemie (International ed. in English) 41 ( 19 ) 3648 - 50 2002.10
-
Bispyrene-Conjugated 2′-O-Methyloligonucleotide as a Highly Specific RNA-Recognition Probe
Mahara, Atsushi, Iwase, Reiko, Sakamoto, Takashi, Yamana, Kazushige, Yamaoka, Tetsuji, Murakami, Akira
Angewandte Chemie ( WILEY-VCH Verlag ) 114 ( 19 ) 3800 - 3802 2002 [Refereed]
-
Study on structure of ribosomal RNA by time-resolved luminescence anisotropy analysis.
T. Sakamoto, A. Mahara, R. Iwase, T. Yamaoka, A. Murakami (Part: Lead author )
Nucleic acids research. Supplement (2001) 1 ( 1 ) 143 - 144 2001 [Refereed]
Books etc
-
Live-Cell RNA Imaging –Methods and Protocols, Ed. Shin-ichi Sato (Ed), Methods in Molecular Biology
Takashi Sakamoto( Part: Contributor, Work: Live-Cell Imaging of RNA G-Quadruplex with a Dual-Color Fluorescence Switch-on Probe)
Springer Nature 2025.01 ISBN: 9781071642474
-
Modified nucleic acids
Nakatani, Kazuhiko, Tor, Yitzhak
Springer 2016 ISBN: 9783319271095
-
新しいDNAチップの科学と応用
関根, 光雄, 講談社サイエンティフィク
講談社 2007.07 ISBN: 9784061538641
Misc
-
Regulating the binding selectivity of dual-color fluorescence switch-on probe that responses with duplex and quadruplex DNA
村岡優香, 安原優, 岩井まり奈, 坂本隆, 坂本隆
日本化学会春季年会講演予稿集(Web) 103rd 2023
-
Development of photochromic DNA imaging probe whose fluorescence properties can be regulated by photoirradiation
三輪好輝, 坂本隆
日本化学会春季年会講演予稿集(Web) 102nd 2022
-
Simultaneous detection of double-stranded and G4 DNAs using a tripodal quinone-cyanine dye
坂本隆, 坂本隆, YU Zehui, 大谷悠人
日本化学会春季年会講演予稿集(Web) 101st 2021
-
Development of a thin layer made of fluorescence turn-on DNA probe and the application for micro-RNA detections
坂本隆
サムコ科学技術振興財団研究報告集 3 2021
-
Label-free in situ Monitoring of DNA Hybridization Chain Reaction Using Sequence-Selective Interaction of Groove Binders with Double-Stranded DNAs
坂本隆, 山田陸斗
日本化学会春季年会講演予稿集(CD-ROM) 100th 2020
-
ヘキスト系色素の非標準構造DNAに対する光反応の検討
三輪好輝, 瀬戸上慧, 坂本隆
日本化学会春季年会講演予稿集(CD-ROM) 99th 2019
-
DNAマイナーグルーブ結合型蛍光色素を用いたハイブリダイゼーション連鎖反応のラベルフリー検出
山田陸斗, 坂本隆, 坂本隆
日本化学会春季年会講演予稿集(CD-ROM) 99th 2019
-
<sup>19</sup>F NMRを用いた核酸等生体分子の同時一斉計測技術の開発
坂本隆, 長谷川大策, QIU Zhiyong, 藤本健造
バイオ・高分子シンポジウム講演要旨集 27th 2017
-
フッ素標識ヘキストプローブを用いた<sup>19</sup>F NMRによるDNA検出
坂本隆, 長谷川大策, 藤本健造
バイオ・高分子シンポジウム講演要旨集 26th 2016
-
<sup>19</sup>F NMRを用いたDNA1塩基多型の同時一斉解析
坂本隆, 長谷川大策, 藤本健造
日本化学会春季年会講演予稿集(CD-ROM) 96th 2016
-
光か学的なRNA架橋反応を用いた新規FISH法の開発
中村重孝, 豊里慧, 狩野千波, 坂本隆, 藤本健造
日本分子生物学会年会プログラム・要旨集(Web) 39th 2016
-
フッ素修飾ビスベンズイミド誘導体を用いた<sup>19</sup>F NMRによるDNAのOFF/ON検出
長谷川大策, 坂本隆, 藤本健造
日本化学会春季年会講演予稿集(CD-ROM) 96th 2016
-
グリシドール骨格を有するDNA光架橋素子の合成とその機能評価
望月卓海, 坂本隆, 藤本健造
日本化学会春季年会講演予稿集(CD-ROM) 96th 2016
-
3-シアノビニルカルバゾールを含む光応答性オリゴDNAプローブを用いた新規FISH法の開発
豊里慧, 坂本隆, 藤本健造
日本化学会春季年会講演予稿集(CD-ROM) 96th 2016
-
Hoechst33258骨格を有するDNA検出<sup>19</sup>F核磁気共鳴プローブの開発
坂本隆, 長谷川大策, 藤本健造
日本化学会講演予稿集 95th ( 3 ) 2015
-
可逆的光架橋反応を用いたシトシンの脱アミノ化反応における相補塩基の効果
大江美成子, 坂本隆, 藤本健造
日本化学会講演予稿集 95th ( 3 ) 2015
-
<sup>19</sup>F核磁気共鳴による核酸検出を可能とする新規分子プローブの開発
坂本隆, 長谷川大策, 藤本健造
バイオ・高分子シンポジウム講演要旨集 25th 2015
-
マルチモードイメージングを目指した新規核酸イメージングプローブの開発
脇田和明, 坂本隆, 藤本健造, 藤本健造
日本化学会講演予稿集 94th ( 3 ) 2014
-
高速光架橋性アンチセンス核酸による定常発現遺伝子の細胞内制御
坂本隆, 滋野敦夫, 大滝優一, 藤本健造, 藤本健造
アンチセンスシンポジウム講演要旨集 24th 2014
-
3-シアノビニルカルバゾールヌクレオシドによるDNA光クロスリンク反応におけるピリミジン5位の置換基効果
村松穂高, 中村重孝, 坂本隆, 藤本健造, 藤本健造
日本化学会講演予稿集 94th ( 3 ) 2014
-
3-シアノビニルカルバゾールとトレオニノール骨格を有する新規DNA・RNA光クロスリンカーの開発
田中佑弥, 坂本隆, 藤本健造, 藤本健造
日本化学会講演予稿集 94th ( 3 ) 2014
-
光架橋性オリゴヌクレオチドによる細胞内遺伝子発現制御法の開発
坂本隆, 滋野敦夫, 大滝優一, 藤本健造, 藤本健造
日本光医学・光生物学会 36th 2014
-
カルバゾール誘導体を含む光応答性アンチセンス核酸を用いた遺伝子発現制御
滋野敦夫, 坂本隆, 藤本健造
日本化学会講演予稿集 93rd ( 3 ) 2013
-
シュードウリジンに対する可逆的光架橋反応の開発
岸里美, 坂本隆, 藤本健造
日本化学会講演予稿集 93rd ( 3 ) 2013
-
三重鎖DNA中における高速光架橋反応開発
吉永広樹, 坂本隆, 藤本健造
日本化学会講演予稿集 93rd ( 3 ) 2013
-
2重鎖DNA光クロスリンク反応に関する反応解析
山田明日香, 坂本隆, 吉村嘉永, 藤本健造
日本化学会講演予稿集 93rd ( 3 ) 2013
-
高速光架橋能をもつアンチセンス核酸による細胞内遺伝子発現制御
坂本隆, 滋野敦夫, 大滝優一, 藤本健造, 藤本健造
アンチセンスシンポジウム講演要旨集 22nd 2012
-
カルバゾール誘導体を用いたDNA光架橋反応機構解析
山田明日香, 坂本隆, 吉村嘉永, 池田真由美, 藤本健造, 藤本健造
高分子学会北陸支部研究発表講演会講演要旨集 61st 2012
-
ビニルカルバゾール含有光応答性人工核酸を用いた光化学的遺伝子発現制御
滋野敦夫, 坂本隆, 藤本健造, 藤本健造
アンチセンスシンポジウム講演要旨集 22nd 2012
-
カルバゾール誘導体によるRNAへの光架橋反応を用いた光化学的な遺伝子発現制御
大滝優一, 滋野敦夫, 坂本隆, 藤本健造
日本分子生物学会年会プログラム・要旨集(Web) 35th 2012
-
三重鎖DNA中における高速光架橋反応開発
吉永広樹, 吉尾泰政, 坂本隆, 藤本健造, 藤本健造
高分子学会北陸支部研究発表講演会講演要旨集 61st 2012
-
高速光架橋能をもつアンチセンス核酸による遺伝子発現制御
大滝優一, 滋野敦夫, 坂本隆, 藤本健造, 藤本健造
高分子学会北陸支部研究発表講演会講演要旨集 61st 2012
-
Pseudouridineに対する可逆的光架橋反応の開発
岸里美, 坂本隆, 藤本健造, 藤本健造
高分子学会北陸支部研究発表講演会講演要旨集 61st 2012
-
<sup>19</sup>F核磁気共鳴による生体分子イメージングを指向したフッ素修飾核酸プローブの合成
坂本隆, 早川輝, 清水勇喜, 佐々木淳, 藤本健造, 藤本健造
有機合成化学セミナー講演予稿集 28th 2011
-
カリウムイオンをセンシングする<sup>19</sup>F MRI用造影プローブの開発
早川輝, 佐々木淳, 坂本隆, 藤本健造, 藤本健造
日本化学会バイオテクノロジー部会シンポジウム講演要旨集 14th 2011
-
光クロスリンクを用いた選択的核酸増幅法の開発
渡邊誉, 坂本隆, 藤本健造
日本化学会講演予稿集 91st ( 3 ) 2011
-
フッ素化合物修飾オリゴDNAを用いた<sup>19</sup>FNMRによる核酸の検出
坂本隆, 清水勇喜, 佐々木淳, 早川輝, 藤本健造, 藤本健造
日本化学会バイオテクノロジー部会シンポジウム講演要旨集 14th 2011
-
カルバゾール誘導体を含む光架橋性アンチセンス核酸による遺伝子発現制御
滋野敦夫, 坂本隆, 藤本健造, 藤本健造
日本化学会バイオテクノロジー部会シンポジウム講演要旨集 14th 2011
-
カリウムイオンをセンシングする19F MRI用造影プローブの開発
早川輝, 坂本隆, 藤本健造
日本化学会講演予稿集 91st ( 3 ) 2011
-
核酸のIn vivoイメージングを目指したフッ素核磁気共鳴OFF/ONプローブの開発:マルチフッ素ラベリングによる検出感度改善
坂本隆, 清水勇喜, 佐々木淳, 早川輝, 藤本健造
日本化学会講演予稿集 91st ( 3 ) 2011
-
光化学的なDNA及びRNAピンポイント編集
二村大樹, 平塚薫, 吉村嘉永, 坂本隆, 藤本健造
日本化学会講演予稿集 91st ( 3 ) 2011
-
可逆的DNA光クロスリンクオリゴによるDNAナノ構造の安定制御
中村重孝, 坂本隆, 藤本健造
日本化学会講演予稿集 91st ( 3 ) 2011
-
核酸のin vivo検出・イメージングのための<sup>19</sup>F核磁気共鳴シグナルOff/Onプローブ
坂本隆, 清水勇喜, 佐々木淳, 藤本健造
日本化学会講演予稿集 90th ( 3 ) 2010
-
遺伝子発現のin vivoイメージングを目指したフッ素核磁気共鳴プローブの開発
坂本隆, 清水勇希, 佐々木淳, 早川輝, 藤本健造
日本化学会バイオテクノロジー部会シンポジウム講演要旨集 13th 2010
-
シアノビニルカルバゾール修飾オリゴDNAを用いた光化学的DNA編集
坂本隆, 池田真由美, 二村大樹, 吉村嘉永, 平塚薫, 藤本健造
日本化学会バイオテクノロジー部会シンポジウム講演要旨集 13th 2010
-
Fluorescence anisotropy-based detection of immunoglobulin G using a long-lifetime fluorophore
坂本隆, 務中達也, 馬原淳, 山形浩一, 山岡哲二, 村上章
日本化学会講演予稿集 84th ( 2 ) 2004
-
マイクロチップを用いた蛍光時間分解偏光解消法による細胞機能の経時的解析
務中達也, 叶井正樹, 藤山陽一, 阿部浩久, 中西博昭, 坂本隆, 馬原淳, 山岡哲二, 村上章
バイオ・高分子シンポジウム講演要旨集 14th 2004
-
Development of long-lifetime Ru(II) complex labeled oligonucleotide for analysis of RNA structure.
坂本隆, 馬原淳, 岩瀬礼子, 山岡哲二, 村上章
日本化学会講演予稿集 79th ( 2 ) 2001
-
長寿命発光能を有するRu(II)錯体を用いたRNA高次構造解析
坂本隆, 馬原淳, 岩瀬礼子, 山岡哲二, 村上章
高分子学会予稿集 50 ( 5 ) 2001
Conference Activities & Talks
-
3脚型キノン-シアニンG4核酸リガンドの光増感活性によるガン細胞選択的アポトーシス誘導
村元順哉, 坂本隆
2024年度北陸地区講演会と研究発表会 2024.11.29
-
新規検出試薬を用いたグアニン四重鎖の解析
成田侑介, 平川哲央, 津崎諒, 中久保政一, 石山宗孝, 坂本 隆
第47回日本分子生物学会年会 2024.11.28
-
3脚型キノンーシアニン色素の光増感活性によるガン細胞選択的アポトーシス誘導
村元順哉, 坂本隆
第18回バイオ関連化学シンポジウム 2024.09.12
-
4重鎖核酸選択的キノン-シアニン色素リガンドによる細胞死の光誘導
村元順哉, 坂本隆
第34回バイオ・高分子シンポジウム 2024.08.02
-
3脚型キノンーシアニン色素への光照射により生成する活性酸素によるアポトーシス誘導
村元順哉, 安原優, 坂本隆
日本ケミカルバイオロジー学会第18回年会 2024.05.28
-
Increased sensitivity of HCR-based nucleic acid detection using the concentration effect of microbeads
Yu Yasuhara, Takashi Sakamoto
日本化学会第103春季年会 2024.03.19
-
核酸4重鎖と2重鎖を見分ける近赤外蛍光プローブ
坂本隆 [Invited]
分子夾雑に挑む化学@和歌山 2023.12.01
-
Fluorescence imaging of nucleic acid quadruplex structure using D3A-type quinone-cyanine fluorescent dyes
Takashi Sakamoto, Yuka Muraoka, Zehui Yu, Mayuko Kawatake
The 50th International Symposium on Nucleic Acids Chemistry (ISNAC2023) 2023.11.02
-
D3A型キノン-シアニン蛍光色素の核酸認識に与えるアクセプター構造の影響
坂本隆, 村岡優香, 于ゾウ慧, 川竹万柚子
第17回バイオ関連化学シンポジウム 2023.09.09
-
D3A 型キノン-シアニン蛍光色素による核酸イメージング
坂本隆, 村岡優香, 于ゾウ慧, 川竹万柚子
第33回バイオ・高分子シンポジウム 2023.07.28
-
DNA2重鎖・4重鎖二色蛍光スイッチオンプローブの結合選択性の制御
村岡 優香, 安原 優, 岩井 まり奈, 坂本 隆
日本化学会第103春季年会 2023.03.22
-
がんの光線力学療法を志向した三脚型キノン−シアニン色素の活性酸素生成能の評価
村元順哉, 安原優, 坂本隆
日本化学会第103春季年会 2023.03.22
-
Controlling the fluorescence response of tripodal quinone-cyanine dyes upon nucleic acid binding
Takashi Sakamoto, Yuka Muraoka, Yu Yasuhara, Marina Iwai
The 49th International Symposium on Nucleic Acids Chemistry (ISNAC2022) 2022.11.03
-
がんの光線力学療法を指向した3脚型キノンーシアニン色素の光増感活性の評価
村元順哉, 安原優, 坂本隆
第16回バイオ関連化学シンポジウム 2022.09.10
-
3脚型キノン-シアニン蛍光色素の核酸構造認識を制御するための化学修飾
村岡優香, 安原優, 岩井まり奈, 坂本隆
第16回バイオ関連化学シンポジウム 2022.09.10
-
生細胞内局所粘度イメージングを目指した3脚型キノンーシアニン近赤外蛍光色素の粘度応答性能の制御
坂本隆, 岩井まり奈
日本ケミカルバイオロジー学会第16回年会 2022.05.31
-
3脚型キノン-シアニン色素誘導体の4重鎖および2重鎖DNAに対する蛍光応答
村岡優香, 安原優, 岩井まり奈, 坂本隆
日本ケミカルバイオロジー学会第16回年会 2022.05.31
-
蛍光特性の光制御が可能なフォトクロミックDNA蛍光イメージングプローブの開発
三輪好輝, 坂本隆
日本化学会第102春季年会 2022.03.24
-
種々のベンゾチアゾリウムカチオン誘導体を含む3脚型キノン-シアニン蛍光色素の核酸に対する蛍光応答
村岡優香, 坂本隆
日本化学会第102春季年会 2022.03.23
-
膜透過性官能基を導入した三脚型キノン−シアニン蛍光色素の合成
大谷悠人, 坂本隆
日本化学会第102春季年会 2022.03.23
-
核酸構造の色分けイメージングを可能とする蛍光プローブの開発
坂本隆 [Invited]
第17回若手技術者交流会(主催:和歌山県化学技術者協会) 2022.03.03
-
A dual fluorescence turn-on probe for simultaneous imaging of double-stranded DNA and G4 DNA
Takashi Sakamoto, Zehui Yu, Yuto Otani
The 48th International Symposium on Nucleic Acids Chemistry (ISNAC2021) 2021.11.12
-
A dual-color fluorescence switch-on probe for imaging the dynamics of guanine quadruplexes in cells
Takashi Sakamoto [Invited]
FIBER Webinar Universe in Nucleic Acids Chemistry 4 2021.11.02
-
DNA構造に選択的な2色蛍光スイッチオンプローブを用いた4重鎖構造形成のリアルタイム追跡
坂本隆, 于ゾウ慧, 大谷悠人
第15回バイオ関連化学シンポジウム 2021.09.10
-
2重鎖と4重鎖を色分けして検出できる蛍光プローブを用いた細胞内DNAイメージング
坂本隆, 于ゾウ慧, 大谷悠人
第31回バイオ・高分子シンポジウム 2021.06.25
-
A Tripodal Quinone-Cyanine Fluorescent Dye for G4 Nucleic Acids Imaging in Cells
Takashi Sakamoto, Zehui Yu, Yuto Otan
日本ケミカルバイオロジー学会第15回年会 2021.06.23
-
多点認識によるねじれ型分子内電荷移動制御に基づく糖検出蛍光プローブの開発
佐藤頌, 坂本隆
日本化学会第101春季年会 2021.03.19
-
三脚型キノン-シアニン蛍光プローブによる2重鎖及び4重鎖DNAの同時検出
坂本隆, 于ゾウ慧, 大谷悠人
日本化学会第101春季年会 2021.03.19
-
ANDゲート型近赤外蛍光分子プローブを用いた細胞核内脱リン酸化酵素活性イメージング
添田嵩章, 坂本隆
日本化学会第101春季年会 2021.03.19
-
低分子蛍光プローブを用いたDNA2重鎖形成連鎖反応のラベルフリー検出系の構築
山田陸斗, 森山貴登, 坂本隆
第30回バイオ・高分子シンポジウム 2020.07.31
-
核内の脱リン酸化酵素活性に応答する近赤外蛍光分子プローブの開発
添田嵩章, 坂本隆
日本化学会第100春季年会 2020.03.24
-
改変型OPA反応と19F NMRを利用したアミノ酸の同時一斉分析
坂本隆, QIU Zhiyong, 稲垣美侑, 藤本健造
日本化学会第100春季年会 2020.03.24
-
グルーブバインダーの2重鎖DNA配列選択的な相互作用を利用したハイブリダイゼーション連鎖反応のラベルフリー検出
坂本隆, 山田陸斗
日本化学会第100春季年会 2020.03.22
-
Label-free in situ monitoring of the DNA hybridization chain reaction by using sequence-selective minor-groove-binding fluorophores
Takashi Sakamoto, Rikuto Yamada
The 46th International Symposium on Nucleic Acids Chemistry (ISNAC2019) 2019.10.29
-
脱リン酸化酵素に応答するANDゲート型DNA検出蛍光プローブの開発
添田嵩章, 坂本隆
第13回バイオ関連化学シンポジウム 2019.09.05
-
DNAマイナーグルーブ結合型蛍光色素を用いたハイブリダイゼーション連鎖反応のラベルフリー検出
山田陸斗, 坂本隆
日本化学会第99春季年会 2019.03.18
-
ヘキスト系色素の非標準構造DNAに対する光反応の検討
三輪好輝, 瀬戸上慧, 坂本隆
日本化学会第99春季年会 2019.03.17
-
19F核磁気共鳴を用いた生体分子の同時一斉計測
坂本隆 [Invited]
2018ハロゲン利用ミニシンポジウム 2018.12.07
-
細胞内ホスファターゼ活性イメージングを指向したANDゲート型蛍光プローブの開発
坂本隆
第28回バイオ・高分子シンポジウム 2018.07.26
-
Development of fluorescent molecular probe for imaging tyrosine phosphatase activity in cell nuclei
Takashi Sakamoto
日本化学会第98春季年会 2018.03.21
-
まとめてイッキに分析!〜生体分子の同時一斉解析技術〜
坂本隆 [Invited]
メディカルジャパン2018大阪 「研究成果企業化促進セミナー」 2018.02.21
-
19F NMR を用いたアミノ酸同時一斉解析法の開発
坂本隆, QIU Zhiyong, 藤本健造
第11回バイオ関連化学シンポジウム 2017.09.08
-
19F NMR を用いた核酸等生体分子の同時一斉計測技術の開発
坂本隆, 長谷川大策, QIU Zhiyong, 藤本健造
第27回バイオ・高分子シンポジウム(2017.7.27) 2017.07.27
-
二本鎖 DNA 中での3ーシアノビニルカルバゾールを用いた光化学的デアミネーションにおけるシトシンの対合塩基の影響
SETHI Siddhant, 大江美成子, 坂本隆, 中村重孝, 藤本健造
日本薬学会第137年会 2017.03.25
-
Development of RNA FISH using photoresponsive molecular beacon probe
Chinami Kano, Kei Toyosato, Takashi Sakamoto, Shigetaka Nakamura, Kenzo Fujimoto
日本化学会第97春季年会 2017.03.17
-
Development of novel molecular devices capable of photo-cross-linking with DNA having specific structures
Takashi Sakamoto, Kenzo Fujimoto
日本化学会第97春季年会 2017.03.17
-
Biomolecule simultaneous analysis by using 19F NMR
Zhiyong Qiu, Takashi Sakamoto, Kenzo Fujimoto
日本化学会第97春季年会 2017.03.16
-
光化学的なRNA架橋反応を用いた新規FISH 法の開発
中村重孝, 豊里慧, 狩野千波, 坂本隆, 藤本健造
第39回日本分子生物学会年会 2016.11.30
-
Evaluation of role of hydrogen bonding in deamination of 3-cyanovinylcarbazole mediated photo-cross-linked cytosine in DNA duplex
Siddhant Sethi, Minako Ooe, Takashi Sakamoto, Kenzo Fujimoto
平成28年度北陸地区講演会と研究発表会 2016.11.25
-
光架橋反応を用いた新規 RNA FISH 法の開発
狩野千波, 豊里慧, 中村重孝, 坂本隆, 藤本健造
平成28年度北陸地区講演会と研究発表会 2016.11.25
-
19F NMRを用いた遊離アミノ酸の同時一斉分析
QIU Zhiyong, 坂本隆, 藤本健造
平成28年度北陸地区講演会と研究発表会 2016.11.25
-
Effects of hydrogen bonding on the cytosine deamination in photo-cross-linked DNA duplex
Siddhant Sethi, Takashi Sakamoto, Kenzo Fujimoto
The 43rd International Symposium on Nucleic Acids Chemistry (ISNAC2016) 2016.09.27
-
RNA FISH using 3-cyanovinylcarbazole-modified ODNs as photo-cross-linking probe
Chinami Kano, Kei Toyosato, Shigetaka Nakamura, Takashi Sakamoto, Kenzo Fujimoto
The 43rd International Symposium on Nucleic Acids Chemistry (ISNAC2016) 2016.09.27
-
Disassembly-driven signal turn-on probe for multimodal detection of DNAs using 19F NMR and fluorescence
Takashi Sakamoto, Daisaku Hasegawa, Kenzo Fujimoto
The 43rd International Symposium on Nucleic Acids Chemistry (ISNAC2016) 2016.09.27
-
蛍光・19F NMRデュアルモードDNA検出を可能とするOFF/ON型分子プローブの開発
坂本隆, 長谷川大策, 藤本健造
第10 回バイオ関連化学シンポジウム 2016.09.07
-
シアノビニルカルバゾールによって光架橋された DNA 上シトシンの脱アミノ化における水素結合の影響
SETHI Siddhant, 坂本隆, 藤本健造
第10 回バイオ関連化学シンポジウム 2016.09.07
-
高速光架橋能を有する蛍光プローブを用いたRNA FISH
狩野 千波, 豊里慧, 中村重孝, 坂本隆, 藤本健造
第10 回バイオ関連化学シンポジウム 2016.09.07
-
改変型OPA反応を利用した迅速アミノ酸分析法の開発
QIU Zhiyong, 坂本隆, 藤本健造
第10 回バイオ関連化学シンポジウム 2016.09.07
-
分子ロボのための核酸光操作ツールの開発
坂本隆 [Invited]
第4回分子ロボ若手会 2016.08.20
-
フッ素標識ヘキストプローブを用いた 19F NMR による DNA 検出
坂本隆, 長谷川大策, 藤本健造
第26 回バイオ・高分子シンポジウム 2016.07.29
-
19F NMRを用いたDNA1塩基多型の同時一斉解析
坂本隆, 長谷川大策, 藤本健造
日本化学会第96春季年会 2016.03.27
-
Development of molecular probes for 19F NMR/fluorescence bimodal detection of DNAs in living cells
Takashi Sakamoto, Daisaku Hasegawa, Kenzo Fujimoto
PACIFICHEM 2015 2015.12.15
-
19F NMR-based analysis of the local sequence and structure of DNAs using fluorine-modified bisbenzimide derivative
Daisaku Hasegawa, Takashi Sakamoto, Kenzo Fujimoto
PACIFICHEM 2015 2015.12.15
-
Development of a novel fluorescence in situ hybridization method using photoreactive oligonuculeotide as a fluorescent probe
Kei Toyosato, Takashi Sakamoto, Kenzo Fujimoto
PACIFICHEM 2015 2015.12.15
-
Photochemical site-directed mutagenesis using 3-cyanovinylcarbazole modified oligodeoxynucleotide
Siddhant Sethi, Minako Ooe, Takashi Sakamoto, Kenzo Fujimoto
The 42nd International Symposium on Nucleic Acids Chemistry (ISNAC2015) 2015.09.23
-
Fluorine-modified bisbenzimide derivative as a molecular probe for simultaneous detection of DNAs by 19F NMR
Takashi Sakamoto, Daisaku Hasegawa, Kenzo Fujimoto
The 42nd International Symposium on Nucleic Acids Chemistry (ISNAC2015) 2015.09.23
-
異なる核酸の同時検出を可能にする新規核酸検出プローブの開発
坂本隆, 長谷川大策, 藤本健造
第9回バイオ関連化学シンポジウム 2015.09.11
-
19F核磁気共鳴による核酸検出を可能とする新規分子プローブの開発
坂本隆, 長谷川大策, 藤本健造
第 25 回バイオ・高分子シンポジウム 2015.07.24
-
蛍光および19F核磁気共鳴によるDNA検出を可能にする新たな分子プローブの開発
坂本隆, 長谷川大策, 藤本健造
日本ケミカルバイオロジー学会第10回年会 2015.06.12
-
Hoechst 33258骨格を有するDNA検出19F核磁気共鳴プローブの開発
坂本隆, 長谷川大策, 藤本健造
日本化学会第95春季年会 2015.03.26
-
Effect of duplex stability on the cytosine deamination using DNA photo-cross-linking reaction
Minako Oe, Takashi Sakamoto, Kenzo Fujimoto
The 41st International Symposium on Nucleic Acids Chemistry (ISNAC2014) 2014.11.05
-
To probe human telomere RNA G-quadruplex structure by 19F NMR
Hong-Liang Bao, Takumi Ishizuka, Takashi Sakamoto, Kenzo Fujimoto, Yan Xu
The 41st International Symposium on Nucleic Acids Chemistry (ISNAC2014) 2014.11.05
-
Short oligonucleotide having 5-fluoro and 5-iodouracil acts as an anticancer prodrug
Mirei Furusawa, Yu-ki Takematsu, Atsuo Shigeno, Takashi Sakamoto, Kenzo Fujimoto
The 41st International Symposium on Nucleic Acids Chemistry (ISNAC2014) 2014.11.05
-
核磁気共鳴法に基づく新たな生体分子検出・イメージングプローブの開発
坂本隆 [Invited]
平成26年度 第1回テニュアトラック制度シンポジウム −生命システムに挑む機能分子の化学– 2014.10.17
-
高速光架橋性アンチセンス核酸による細胞内遺伝子発現の光制御
坂本隆, 滋野敦夫, 大滝優一, 藤本 健造
第8回バイオ関連化学シンポジウム 2014.09.12
-
高速光架橋性アンチセンス核酸による細胞内遺伝子発現制御
坂本隆, 滋野敦夫, 大滝優一, 藤本 健造
アンチセンス・遺伝子・デリバリーシンポジウム2014 2014.09.08
-
光架橋性オリゴヌクレオチドによる細胞内遺伝子発現制御法の開発
坂本隆, 滋野敦夫, 大滝優一, 藤本健造
第36回日本光医学・光生物学会 2014.07.25
-
高速光架橋性オリゴヌクレオチドによる細胞内遺伝子発現制御
坂本隆, 滋野敦夫, 大滝優一, 藤本健造
日本ケミカルバイオロジー学会第9回年会 2014.06.12
Patents
-
アミノ酸分析法
Patent no: 6725144
Date registered: 2020.06.29
Date applied: 2016.09.06 ( 特願2016-173792 ) Publication date: 2018.03.15 ( 特開2018-39747 )
Inventor(s)/Creator(s): 坂本隆 Applicant: 国立大学法人和歌山大学
-
核酸検出方法、化合物、及び蛍光プローブ
米国
Date applied: 2021.11.30 ( 18/266187 )
Inventor(s)/Creator(s): 坂本 隆 Applicant: 国立大学法人和歌山大学
-
核酸検出方法、化合物、及び蛍光プローブ
欧州
Date applied: 2021.11.30 ( 21903252.1 )
Inventor(s)/Creator(s): 坂本 隆 Applicant: 国立大学法人和歌山大学
-
核酸検出方法、化合物、及び蛍光プローブ
Date applied: 2020.12.11 ( 特願2020-206368 ) Public disclosure date: 2022.06.16 ( WO2022/124148 )
Inventor(s)/Creator(s): 坂本 隆 Applicant: 国立大学法人和歌山大学
Research Exchange
-
ライフサイエンス分野 新技術説明会
2018.01 -
第26回わかやまテクノビジネスフェア
2017.11 -
大阪府立大学・和歌山大学工学研究シーズ合同発表会
2017.10
KAKENHI
-
三脚型キノン-シアニン色素の特徴を活かした4重鎖核酸イメージング蛍光色素の開発
2021.04-2024.03Grant-in-Aid for Scientific Research(C) Principal investigator
-
超高速光クロスリンクを用いたゲノム操作法の開発
2017.04-2020.03Grant-in-Aid for Scientific Research(B) Co-investigator
-
DNA捕捉・放出能力をもつ多機能性ペプチド・ゲル・リポソームの創出
2015.04-2017.03Grant-in-Aid for Scientific Research on Innovative Areas(Research in a Proposed Research Area) Principal investigator
-
レシオ変化型核磁気共鳴プローブによる核酸の同時並列的検出法の開発
2015.04-2017.03Grant-in-Aid for Young Scientists(B) Principal investigator
-
光架橋反応を用いた19F-NMRによる核酸類検出法の開発
2014.04-2017.03Grant-in-Aid for Scientific Research(B) Co-investigator
Instructor for open lecture, peer review for academic journal, media appearances, etc.
-
投稿論文の査読
2024.06Bioorganic Medicinal Chemistry Letters
-
投稿論文の査読
2024.05European Journal of Organic Chemistry
-
投稿論文の査読
2023.12Theranostics
-
投稿論文の査読
2022.12Analytical Chemistry, ACS
-
「第2回Challenge万博」での講演
2022.11.24関西イノベーションイニシアティブ(KSII)、三井住友銀行
-
和歌山県化学技術者協会講演会での講演
2022.11.14和歌山県化学技術者協会
-
MOBIO産学連携オフィス テーマ別合同シーズ発表会 「万博」での講演
2022.10.18公益財団法人大阪産業局
-
関西バイオビジネスマッチング2022での講演
2022.10.03-2022.11.18バイオコミュニティ関西(BiocK)・NPO法人近畿バイオインダストリー振興会議
-
投稿論文の査読
2022.10Analytical Chemistry, ACS
-
投稿論文の査読
2022.09Organic & Biomolecular Chemistry, RSC
-
投稿論文の査読
2022.05Chemistry and Biodiversity
-
投稿論文の査読
2022.04Bioorganic Chemistry
-
第17回若手技術者交流会での講演
2022.03.03和歌山県化学技術者協会
-
投稿論文の査読
2022.03Chemistry and Biodiversity, Wiley-VCH
-
投稿論文の査読
2021.11Magnetic Resonance in Chemistry, Wiley-VCH
-
投稿論文の査読
2021.10Advanced Functional Materials, Wiley-VCH
-
投稿論文の査読
2021.09ACSOmega, American Chemical Society
-
イノベーションジャパン 2021 ~大学見本市 Online での講演
2021.08.23-2021.09.17科学技術振興機構
-
投稿論文の査読
2021.08Organic & Biomolecular Chemistry, Royal Society of Chemistry
-
夢ナビライブでの高校生向けのオンライン講演
2021.04-2021.07株式会社 フロムページ
-
投稿論文の査読
2021.04Analytica Chimica Acta, Elsevier
-
投稿論文の査読
2021.04Organic & Biomolecular Chemistry, Royal Society of Chemistry
-
投稿論文の査読
2020.04-2021.01Biomaterials Science, Royal Society of Chemistry
-
投稿論文の査読
2020.04-2020.09ChemBioChem, Wiley-VCH
-
投稿論文の査読
2020.04-2020.08Organic & Biomolecular Chemistry, Royal Society of Chemistry
-
投稿論文の査読
2020.04-2020.05ChemBioChem, Wiley-VCH
-
講師
2018.02.21「メディカルジャパン2018大阪」研究成果企業化促進セミナー
-
研究者交流会(精密物質学科 卒業研究発表会 午前の部終了後)
2016.04和歌山大学システム工学部精密物質学科
Committee member history in academic associations, government agencies, municipalities, etc.
-
口頭発表 座長
2021.03.19日本化学会第101春季年会(日本化学会)
Other Social Activities
-
「第2回Challenge万博」での講演
2022.11.24関西イノベーションイニシアティブ(KSII)、三井住友銀行
-
MOBIO産学連携オフィス テーマ別合同シーズ発表会 「万博」での講演
2022.10.18公益財団法人大阪産業局
-
関西バイオビジネスマッチング2022での講演
2022.10.03-2022.11.18バイオコミュニティ関西(BiocK)・NPO法人近畿バイオインダストリー振興会議
-
イノベーション・ジャパン2021~大学見本市Online
2021.08.23-2021.09.17その他
-
和歌山県化学技術者協会 講演会
2019.04-2020.03その他