Published Papers - SAKAMOTO Takashi

Tripodal Quinone-Cyanine G-Quadruplex Ligands as Novel Photosensitizers on Photoinduced Cancer Cell Death

Junya Muramoto, Takashi Sakamoto （Part： Last author,　Corresponding author )

Molecules     2024.10  [Refereed]  [Invited]

DOI

Near-Infrared Fluorescent Switch-On Probe for Guanine-Quadruplex Imaging with Extremely Large Stokes Shift

Yuka Muraoka, Junya Muramoto, Yu Yasuhara, Mayuko Kawatake, Takashi Sakamoto （Part： Last author,　Corresponding author )

Analytical Chemistry ( American Chemical Society (ACS) )  95 ( 47 ) 17162 - 17165   2023.11  [Refereed]

DOI

Tripodal Quinone-cyanine Fluorescent Dye as a Tool for Analyzing Structural Dynamics of DNA Guanine-quadruplex

Takashi Sakamoto, Zehui Yu （Part： Lead author,　Corresponding author )

Chemistry Letters ( The Chemical Society of Japan )  51 ( 12 ) 1139 - 1142   2022.12  [Refereed]

DOI

Dual-Color Fluorescence Switch-On Probe for Imaging G-Quadruplex and Double-Stranded DNA in Living Cells

Takashi Sakamoto, Zehui Yu, Yuto Otani （Part： Lead author,　Corresponding author )

Analytical Chemistry ( American Chemical Society ({ACS}) )  94 ( 10 ) 4269 - 4276   2022.03  [Refereed]

DOI

Simultaneous Amino Acid Analysis Based on ¹⁹F NMR Using a Modified OPA-Derivatization Method

Takashi Sakamoto, Zhiyong Qiu, Miyu Inagaki, Kenzo Fujimoto （Part： Lead author,　Corresponding author )

Analytical Chemistry ( American Chemical Society (ACS) )  92 ( 2 ) 1669 - 1673   2019.12  [Refereed]

DOI

Front Cover: Label‐Free in Situ Monitoring of the DNA Hybridization Chain Reaction by Using Sequence‐Selective Minor‐Groove‐Binding Fluorophores (ChemBioChem 10/2019)

Takashi Sakamoto, Rikuto Yamada

ChemBioChem ( Wiley )  20 ( 10 ) 1206 - 1206   2019.05

DOI

Photo-cross-linkable artificial nucleic acid: Synthesis and properties of 3-cyanovinylcarbazole-modified nucleic acids and its photo-induced gene-silencing activity in cells

Takashi Sakamoto, Kenzo Fujimoto （Part： Lead author )

Synthesis of Therapeutic Oligonucleotides     171 - 186   2018.12  [Refereed]

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© Springer Nature Singapore Pte Ltd. 2018. The inter-strand photo-cross-linking reaction between nucleic acid strands has wide potential for regulating gene expression specifically and spatiotemporally due to its sequence specificity and high photo irradiation operability. Therefore, photo-cross-linkable artificial nucleic acids are required to be specific and effective drugs without adverse effects and also be good tools for investigating gene functions in cells. As one of the most reactive photo-cross-linkable artificial nucleic acids, in this review, 3-cyanovinylcarbazole modified oligodeoxyribonucleotides that can photo-crosslink with their complementary nucleic acid within a few seconds of photoirradiation are examined. The details of the synthetic method, properties and the applications for regulating gene expression in cells are discussed.

DOI

Disassembly-driven signal turn-on probes for bimodal detection of DNA with 19F NMR and fluorescence

Takashi Sakamoto, Daisaku Hasegawa, Kenzo Fujimoto （Part： Lead author,　Corresponding author )

Organic & Biomolecular Chemistry ( Royal Society of Chemistry ({RSC}) )    2018  [Refereed]

DOI

Effect of nucleobase change on cytosine deamination through DNA photo-cross-linking reaction via 3-cyanovinylcarbazole nucleoside.

Sethi S, Ooe M, Sakamoto T, Fujimoto K

    2017.04  [Refereed]

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Sethi S, Ooe M, Sakamoto T, Fujimoto K, Molecular bioSystems, 2017, 2017

DOI

Characterization of human telomere RNA G-quadruplex structures in vitro and in living cells using 19F NMR spectroscopy.

Bao HL, Ishizuka T, Sakamoto T, Fujimoto K, Uechi T, Kenmochi N, Xu Y

    2017.02  [Refereed]

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Bao HL, Ishizuka T, Sakamoto T, Fujimoto K, Uechi T, Kenmochi N, Xu Y, Nucleic acids research, 2017, 2017

DOI

UVA-responsive Anticancer Prodrugs Based on Photoinduced Electron Injection into Oligonucleotide Having 5-Halouracils

Fujimoto, Kenzo, Furusawa, Mirei, Nakamura, Shigetaka, Sakamoto, Takashi （Part： Last author )

Chemistry Letters ( The Chemical Society of Japan )  45 ( 9 ) 1078 - 1080   2016.06  [Refereed]

DOI

Simultaneous detection of single-nucleotide polymorphisms in a DNA bulge structure using a fluorine-modified bisbenzimide derivative

Sakamoto, Takashi, Hasegawa, Daisaku, Fujimoto, Kenzo （Part： Lead author,　Corresponding author )

Analyst ( Royal Society of Chemistry )  141 ( 4 ) 1214 - 1217   2016.02  [Refereed]

DOI

Photo-Cross-Linking Reaction in Nucleic Acids: Chemistry and Applications

Sakamoto, Takashi, Fujimoto, Kenzo （Part： Lead author )

Modified Nucleic Acids ( Springer )    145 - 157   2016  [Refereed]

RNA fluorescence in situ hybridization using 3-cyanovinylcarbazole modified oligodeoxyribonucleotides as photo-cross-linkable probes

Fujimoto, Kenzo, Toyosato, Kei, Nakamura, Shigetaka, Sakamoto, Takashi （Part： Last author )

Bioorganic & Medicinal Chemistry Letters ( Pergamon )  26 ( 21 ) 5312 - 5314   2016  [Refereed]

DOI

Critical effect of base pairing of target pyrimidine on the interstrand photo-cross-linking of DNA via 3-cyanovinylcarbazole nucleoside

Sakamoto, Takashi, Ooe, Minako, Fujimoto, Kenzo （Part： Lead author )

Bioconjugate chemistry ( ACS Publications )  26 ( 8 ) 1475 - 1478   2015  [Refereed]

DOI

DNA photo-cross-linking using 3-cyanovinylcarbazole modified oligonucleotide with threoninol linker

Sakamoto, Takashi, Tanaka, Yuya, Fujimoto, Kenzo （Part： Lead author )

Organic letters ( ACS Publications )  17 ( 4 ) 936 - 939   2015  [Refereed]

DOI

Changing blue fluorescent protein to green fluorescent protein using chemical RNA editing as a novel strategy in genetic restoration

Vu, Luyen T, Nguyen, Thanh TK, Alam, Shafiul, Sakamoto, Takashi, Fujimoto, Kenzo, Suzuki, Hitoshi, Tsukahara, Toshifumi

Chemical biology & drug design ( Wiley Online Library )  86 ( 5 ) 1242 - 1252   2015  [Refereed]

DOI

Fluorine-modified bisbenzimide derivative as a molecular probe for bimodal and simultaneous detection of DNAs by 19 F NMR and fluorescence

Sakamoto, Takashi, Hasegawa, Daisaku, Fujimoto, Kenzo （Part： Lead author,　Corresponding author )

Chemical Communications ( Royal Society of Chemistry )  51 ( 42 ) 8749 - 8752   2015  [Refereed]

DOI

Short oligonucleotide prodrug having 5-fluoro and 5-iodouracil inhibits the proliferation of cancer cells in a photo-responsive manner

Fujimoto, Kenzo, Takematsu, Yu-ki, Shigeno, Atsuo, Furusawa, Mirei, Sakamoto, Takashi （Part： Last author )

Bioorganic & medicinal chemistry letters ( Elsevier )  24 ( 16 ) 3736 - 3738   2014  [Refereed]

DOI

Photo-regulation of constitutive gene expression in living cells by using ultrafast photo-cross-linking oligonucleotides

Sakamoto, Takashi, Shigeno, Atsuo, Ohtaki, Yuichi, Fujimoto, Kenzo （Part： Lead author )

Biomaterials Science ( Royal Society of Chemistry )  2 ( 9 ) 1154 - 1157   2014  [Refereed]

DOI