論文 - 坂本　隆

Tripodal Quinone-Cyanine G-Quadruplex Ligands as Novel Photosensitizers on Photoinduced Cancer Cell Death

Junya Muramoto, Takashi Sakamoto (担当区分： 最終著者,　責任著者 )

Molecules     2024年10月  [査読有り]  [招待有り]

DOI

Near-Infrared Fluorescent Switch-On Probe for Guanine-Quadruplex Imaging with Extremely Large Stokes Shift

Yuka Muraoka, Junya Muramoto, Yu Yasuhara, Mayuko Kawatake, Takashi Sakamoto (担当区分： 最終著者,　責任著者 )

Analytical Chemistry ( American Chemical Society (ACS) )  95 ( 47 ) 17162 - 17165   2023年11月  [査読有り]

DOI

Tripodal Quinone-cyanine Fluorescent Dye as a Tool for Analyzing Structural Dynamics of DNA Guanine-quadruplex

Takashi Sakamoto, Zehui Yu (担当区分： 筆頭著者,　責任著者 )

Chemistry Letters ( The Chemical Society of Japan )  51 ( 12 ) 1139 - 1142   2022年12月  [査読有り]

DOI

Dual-Color Fluorescence Switch-On Probe for Imaging G-Quadruplex and Double-Stranded DNA in Living Cells

Takashi Sakamoto, Zehui Yu, Yuto Otani (担当区分： 筆頭著者,　責任著者 )

Analytical Chemistry ( American Chemical Society ({ACS}) )  94 ( 10 ) 4269 - 4276   2022年03月  [査読有り]

DOI

Simultaneous Amino Acid Analysis Based on ¹⁹F NMR Using a Modified OPA-Derivatization Method

Takashi Sakamoto, Zhiyong Qiu, Miyu Inagaki, Kenzo Fujimoto (担当区分： 筆頭著者,　責任著者 )

Analytical Chemistry ( American Chemical Society (ACS) )  92 ( 2 ) 1669 - 1673   2019年12月  [査読有り]

DOI

Front Cover: Label‐Free in Situ Monitoring of the DNA Hybridization Chain Reaction by Using Sequence‐Selective Minor‐Groove‐Binding Fluorophores (ChemBioChem 10/2019)

Takashi Sakamoto, Rikuto Yamada

ChemBioChem ( Wiley )  20 ( 10 ) 1206 - 1206   2019年05月

DOI

Photo-cross-linkable artificial nucleic acid: Synthesis and properties of 3-cyanovinylcarbazole-modified nucleic acids and its photo-induced gene-silencing activity in cells

Takashi Sakamoto, Kenzo Fujimoto (担当区分： 筆頭著者 )

Synthesis of Therapeutic Oligonucleotides     171 - 186   2018年12月  [査読有り]

　概要を見る

© Springer Nature Singapore Pte Ltd. 2018. The inter-strand photo-cross-linking reaction between nucleic acid strands has wide potential for regulating gene expression specifically and spatiotemporally due to its sequence specificity and high photo irradiation operability. Therefore, photo-cross-linkable artificial nucleic acids are required to be specific and effective drugs without adverse effects and also be good tools for investigating gene functions in cells. As one of the most reactive photo-cross-linkable artificial nucleic acids, in this review, 3-cyanovinylcarbazole modified oligodeoxyribonucleotides that can photo-crosslink with their complementary nucleic acid within a few seconds of photoirradiation are examined. The details of the synthetic method, properties and the applications for regulating gene expression in cells are discussed.

DOI

Disassembly-driven signal turn-on probes for bimodal detection of DNA with 19F NMR and fluorescence

Takashi Sakamoto, Daisaku Hasegawa, Kenzo Fujimoto (担当区分： 筆頭著者,　責任著者 )

Organic & Biomolecular Chemistry ( Royal Society of Chemistry ({RSC}) )    2018年  [査読有り]

DOI

Effect of nucleobase change on cytosine deamination through DNA photo-cross-linking reaction via 3-cyanovinylcarbazole nucleoside.

Sethi S, Ooe M, Sakamoto T, Fujimoto K, Molecular bioSystems

    2017年04月  [査読有り]

　概要を見る

Sethi S, Ooe M, Sakamoto T, Fujimoto K, Molecular bioSystems, 2017, 2017

DOI

Characterization of human telomere RNA G-quadruplex structures in vitro and in living cells using 19F NMR spectroscopy.

Bao HL, Ishizuka T, Sakamoto T, Fujimoto K, Uechi T, Kenmochi N, Xu Y, Nucleic acids research

    2017年02月  [査読有り]

　概要を見る

Bao HL, Ishizuka T, Sakamoto T, Fujimoto K, Uechi T, Kenmochi N, Xu Y, Nucleic acids research, 2017, 2017

DOI

UVA-responsive Anticancer Prodrugs Based on Photoinduced Electron Injection into Oligonucleotide Having 5-Halouracils

Fujimoto Kenzo, Furusawa Mirei, Nakamura Shigetaka, Sakamoto Takashi (担当区分： 最終著者 )

Chemistry Letters ( The Chemical Society of Japan )  45 ( 9 ) 1078 - 1080   2016年06月  [査読有り]

DOI

Simultaneous detection of single-nucleotide polymorphisms in a DNA bulge structure using a fluorine-modified bisbenzimide derivative

Sakamoto Takashi, Hasegawa Daisaku, Fujimoto Kenzo (担当区分： 筆頭著者,　責任著者 )

Analyst ( Royal Society of Chemistry )  141 ( 4 ) 1214 - 1217   2016年02月  [査読有り]

DOI

Photo-Cross-Linking Reaction in Nucleic Acids: Chemistry and Applications

Sakamoto Takashi, Fujimoto Kenzo (担当区分： 筆頭著者 )

Modified Nucleic Acids ( Springer )    145 - 157   2016年  [査読有り]

RNA fluorescence in situ hybridization using 3-cyanovinylcarbazole modified oligodeoxyribonucleotides as photo-cross-linkable probes

Fujimoto Kenzo, Toyosato Kei, Nakamura Shigetaka, Sakamoto Takashi (担当区分： 最終著者 )

Bioorganic & Medicinal Chemistry Letters ( Pergamon )  26 ( 21 ) 5312 - 5314   2016年  [査読有り]

DOI

Critical effect of base pairing of target pyrimidine on the interstrand photo-cross-linking of DNA via 3-cyanovinylcarbazole nucleoside

Sakamoto Takashi, Ooe Minako, Fujimoto Kenzo (担当区分： 筆頭著者 )

Bioconjugate chemistry ( ACS Publications )  26 ( 8 ) 1475 - 1478   2015年  [査読有り]

DOI

DNA photo-cross-linking using 3-cyanovinylcarbazole modified oligonucleotide with threoninol linker

Sakamoto Takashi, Tanaka Yuya, Fujimoto Kenzo (担当区分： 筆頭著者 )

Organic letters ( ACS Publications )  17 ( 4 ) 936 - 939   2015年  [査読有り]

DOI

Changing blue fluorescent protein to green fluorescent protein using chemical RNA editing as a novel strategy in genetic restoration

Vu Luyen T, Nguyen Thanh TK, Alam Shafiul, Sakamoto Takashi, Fujimoto Kenzo, Suzuki Hitoshi, Tsukahara Toshifumi

Chemical biology & drug design ( Wiley Online Library )  86 ( 5 ) 1242 - 1252   2015年  [査読有り]

DOI

Fluorine-modified bisbenzimide derivative as a molecular probe for bimodal and simultaneous detection of DNAs by 19 F NMR and fluorescence

Sakamoto Takashi, Hasegawa Daisaku, Fujimoto Kenzo (担当区分： 筆頭著者,　責任著者 )

Chemical Communications ( Royal Society of Chemistry )  51 ( 42 ) 8749 - 8752   2015年  [査読有り]

DOI

Short oligonucleotide prodrug having 5-fluoro and 5-iodouracil inhibits the proliferation of cancer cells in a photo-responsive manner

Fujimoto Kenzo, Takematsu Yu-ki, Shigeno Atsuo, Furusawa Mirei, Sakamoto Takashi (担当区分： 最終著者 )

Bioorganic & medicinal chemistry letters ( Elsevier )  24 ( 16 ) 3736 - 3738   2014年  [査読有り]

DOI

Photo-regulation of constitutive gene expression in living cells by using ultrafast photo-cross-linking oligonucleotides

Sakamoto Takashi, Shigeno Atsuo, Ohtaki Yuichi, Fujimoto Kenzo (担当区分： 筆頭著者 )

Biomaterials Science ( Royal Society of Chemistry )  2 ( 9 ) 1154 - 1157   2014年  [査読有り]

DOI